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Study of the effect of different phosphodiesterase (1,3,5) inhibitors on diclofenac-induced acute renal failure in rats / Nermeen Salah Eldeen Abdelrazek Ismail ; Supervised Hesham Aly Salem , Walaa Wadie Ibrahim

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Nermeen Salah Eldeen Abdelrazek Ismail , 2020Description: 114 P . : charts ; 25cmOther title:
  • دراسة تأثير مثبطات الفوسفودايستيراز ( 1و3و5) فى الفشل الكلوى الحاد الناجم عن الديكلوفيناك فى الجرذان [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: Acute renal failure (ARF) is common especially when non steroidal anti-inflammatory drugs (NSAIDS) are used for longer period of time or at greater doses (Efrati et al., 2007). The aim of the present study was to investigate the potential nephroprotective effects of different phosphodiesterase (PDE) inhibitors, namely pentoxifylline, vinpocetine, cilostazol and sildenafil, in diclofenac-induced ARF in rats and to throw some light on their mechanism(s) of action. Pentoxifylline (100 mg/kg/day), vinpocetine (20 mg/kg/day), cilostazol (50 mg/kg/day) and sildenafil (5 mg/kg/day) were orally administered for 6 consecutive days. Renal failure was then induced by i.p. injection of diclofenac sodium (15 mg/kg) on days 4, 5, and 6 in all groups except control group
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2020.Ne.S (Browse shelf(Opens below)) Not for loan 01010110081928000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2020.Ne.S (Browse shelf(Opens below)) 81928.CD Not for loan 01020110081928000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Acute renal failure (ARF) is common especially when non steroidal anti-inflammatory drugs (NSAIDS) are used for longer period of time or at greater doses (Efrati et al., 2007). The aim of the present study was to investigate the potential nephroprotective effects of different phosphodiesterase (PDE) inhibitors, namely pentoxifylline, vinpocetine, cilostazol and sildenafil, in diclofenac-induced ARF in rats and to throw some light on their mechanism(s) of action. Pentoxifylline (100 mg/kg/day), vinpocetine (20 mg/kg/day), cilostazol (50 mg/kg/day) and sildenafil (5 mg/kg/day) were orally administered for 6 consecutive days. Renal failure was then induced by i.p. injection of diclofenac sodium (15 mg/kg) on days 4, 5, and 6 in all groups except control group

Issued also as CD

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