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Measurement of Klotho as a marker of osteoporosis in Egyptian sickle cell disease patients / Basma Samir Ali Mohamed ; Supervised Mona Mohamed Hamdy , Iman AbdelMohsen Shaheen , Hadeel Mohamed Seifeldin

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Basma Samir Ali Mohamed , 2020Description: 122 P . : charts , facsmilies ; 25cmOther title:
  • قياس كلوثو كعلامة لهشاشة العظام فى مرضى الخلية المنجلية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Summary: Introduction: Bone and joint disorders are the most common cause of chronic pain in sickle cell disease patients with many complications including osteopenia and osteoporosis. Klotho protein, whose gene has predominant renal expression, acts in the control of serum phosphorus and 1,25-dihydroxyvitamin D3 which may be implicated in onset of osteopenia and osteoporosis. Objective: Our study aimed to measure serum Klotho level by enzyme linked immune sorbent assay as a marker of osteoporosis in sickle cell disease patients in correlation with Dual Energy X- ray Absorptiometry scan. Patients and methods: This was a cross-sectional study which included 60 (sixty) sickle disease patients who were performing routine follow up at the Hematology clinic of children Hospital Cairo University in addition to 30 (thirty) age and sex matched healthy control subjects .All of the included patients were subjected to full history taking, examination, investigations including Dual Energy X-ray Absorptiometry scan and Klotho level
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2020.Ba.M (Browse shelf(Opens below)) Not for loan 01010110081950000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2020.Ba.M (Browse shelf(Opens below)) 81950.CD Not for loan 01020110081950000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Introduction: Bone and joint disorders are the most common cause of chronic pain in sickle cell disease patients with many complications including osteopenia and osteoporosis. Klotho protein, whose gene has predominant renal expression, acts in the control of serum phosphorus and 1,25-dihydroxyvitamin D3 which may be implicated in onset of osteopenia and osteoporosis. Objective: Our study aimed to measure serum Klotho level by enzyme linked immune sorbent assay as a marker of osteoporosis in sickle cell disease patients in correlation with Dual Energy X- ray Absorptiometry scan. Patients and methods: This was a cross-sectional study which included 60 (sixty) sickle disease patients who were performing routine follow up at the Hematology clinic of children Hospital Cairo University in addition to 30 (thirty) age and sex matched healthy control subjects .All of the included patients were subjected to full history taking, examination, investigations including Dual Energy X-ray Absorptiometry scan and Klotho level

Issued also as CD

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