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Implication of mirna 153 on PTEN expression in prostatic adenocarcinoma / Enas Ismail Ali Elnahas ; Supervised Ali Ahmed Elhindawi , Tarek Salaheldin Aboushousha , Dalal Anwar Elwi

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Enas Ismail Ali Elnahas , 2020Description: 147 P . : charts , facsmilies ; 25cmOther title:
  • فى سرطان البروستاتاPTENتاثير الميكرون 153 على إظهار البروتين [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: Background: Prostate cancer (PCa) is the second most common cancer in men with increasing incidence with age. Under normal circumstances, MicroRNAs (miRNAs) can generate different functions for regulating RNA protein levels and balancing abnormalities. Some authors suggest that miRNA153 plays an important role in promoting proliferation of human prostate cancer cells and presents a novel mechanism of miRN mediated direct suppression of PTEN expression in prostate cancer. AIM: evaluation of implication of miRNA 153 on PTEN expression in Prostatic adenocarcinoma in Egyptian patients and its impact on diagnosis and possible target therapy. MATERIAL&METHODS: a case control study included 80 prostatic adenocarcinoma archival blocks& 20 benign prostatic hyperplasia blocks as a control, Detection of PTEN by Immunohistochemical (IHC) technique and miRNA 153 by In Situ Hybridization (ISH) technique
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2020.En.I (Browse shelf(Opens below)) Not for loan 01010110082031000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2020.En.I (Browse shelf(Opens below)) 82031.CD Not for loan 01020110082031000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology

Background: Prostate cancer (PCa) is the second most common cancer in men with increasing incidence with age. Under normal circumstances, MicroRNAs (miRNAs) can generate different functions for regulating RNA protein levels and balancing abnormalities. Some authors suggest that miRNA153 plays an important role in promoting proliferation of human prostate cancer cells and presents a novel mechanism of miRN mediated direct suppression of PTEN expression in prostate cancer. AIM: evaluation of implication of miRNA 153 on PTEN expression in Prostatic adenocarcinoma in Egyptian patients and its impact on diagnosis and possible target therapy. MATERIAL&METHODS: a case control study included 80 prostatic adenocarcinoma archival blocks& 20 benign prostatic hyperplasia blocks as a control, Detection of PTEN by Immunohistochemical (IHC) technique and miRNA 153 by In Situ Hybridization (ISH) technique

Issued also as CD

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