Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine

Background and objective: The neutrophil-to-lymphocyte ratio & mean platelet volume has demonstrated to be prognostic inflammatory markers in cardiovascular disease. The objective of this study is to evaluate the value of neutrophil-lymphocyte ratio and mean platelet volume as a prognostic marker for major adverse cardiac events in ACS patients. Materials and methods: we analyze 107 acute coronary syndrome patients. The patients were divided into three groups STEMI, NSTE-ACS and UA. We evaluated the incidence of major adverse cardiac events (MACE), a composite of all causes of death, non-fatal MI, and ischemic stroke during follow up for 3 months. Patients characteristics and the complete blood count (CBC) variables, including white blood cell (WBC), hemoglobin (Hb), platelet count, NLR, as well as AST, ALT, and other routine biochemical parameters were tested. Data analyses were conducted with SPSS-15 software (SPSS Inc., Chicago, Illinois, USA). Statistical significance was set at a p-value of <0.05. Results: we analyze 107 acute coronary syndrome patients. Of which 71 males & 36 females with past medical history as 66 (61.7%) was Hypertension, 56 (52.3%) was Smoking, 53 (49.5%) was DM, 53 (49.5%) showed Obesity, 30 (28.0%) showed Dyslipidemia. The MACE occurred in 6 (22.2%) females and 21 (77.8%) males. 16 (59.3%) of Hypertension had MACE. 13 (48.1 %) of D.M had MACE. 13 (48.1 %) of Obesity patients had MACE. 10 (37.0 %) of Dyslipidemia patients had MACE. The occurrence of MACE was related significantly to the mean MPV (day 1, 2), as the MPV increase MACE increase. On the other hand, the occurrence of MACE has no relation to the mean NLR

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