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Synthesis and application of molecularly imprinted polymers for the antiviral drug sofosbuvir / Muhammed Abdelhamied Abdeltawab Abdelhamied ; Supervised Rasha Mohamed Elnashar , Muhammad Gamal Abdelmoghny

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Muhammed Abdelhamied Abdeltawab Abdelhamied , 2020Description: 123 P . : charts , facsmilies ; 25cmOther title:
  • تحضير وتطبيق بوليمرات جزيئية الطباعة لعقار سوفوسبوفير المضاد للفيروسات [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Analytical Chemistry Summary: In this work, a biomimetic electrochemical sensor for sofosbuvir (SOFO) was designed and optimized for its determination in pure forms,pharmaceutical formulations, urine besides forced degradation products. Computational calculations, based on density functional theory (DFT) at the B3LYP/6-31G(d) level, were initially employed to screen some of the commonly used electropolymerizable functional monomers including para-aminothiophenol(PTP),ortho-aminophenol (OAP), ortho-phenylenediamine(OPD),and pyrrole (PY). Based on the computational calculations,the imprinted sensor active sites were engineered via electropolymerization of OAP, which was found to show the highest binding efficiency to the target drug, on a glassy carbon electrode(GCE)modified with functionalized multi-walled carbon nanotubes(f-MWCNTs)and reduced graphene oxide (RGO) nanocomposite for sensitive determination of SOFO
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.08.M.Sc.2020.Mu.S (Browse shelf(Opens below)) Not for loan 01010110082087000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.08.M.Sc.2020.Mu.S (Browse shelf(Opens below)) 82087.CD Not for loan 01020110082087000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Analytical Chemistry

In this work, a biomimetic electrochemical sensor for sofosbuvir (SOFO) was designed and optimized for its determination in pure forms,pharmaceutical formulations, urine besides forced degradation products. Computational calculations, based on density functional theory (DFT) at the B3LYP/6-31G(d) level, were initially employed to screen some of the commonly used electropolymerizable functional monomers including para-aminothiophenol(PTP),ortho-aminophenol (OAP), ortho-phenylenediamine(OPD),and pyrrole (PY). Based on the computational calculations,the imprinted sensor active sites were engineered via electropolymerization of OAP, which was found to show the highest binding efficiency to the target drug, on a glassy carbon electrode(GCE)modified with functionalized multi-walled carbon nanotubes(f-MWCNTs)and reduced graphene oxide (RGO) nanocomposite for sensitive determination of SOFO

Issued also as CD

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