Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of E.N.T

Background: Migraine patients appear to process auditory information differently. Functional, electrophysiological alterations and cognitive impairment have been found abundantly in migrainous. Objective: to assess auditory cognitive function and central auditory functions in adult migraine patients. Subjects and methods: Sixty adult individuals with migraine participated as the migraine group with sixty age and gender matched nonmigrainures individuals as the control group. All subjects were submitted to full history taking, Mini-Mental State Examination (MMSE), symbol digits modality test (SDMT), basic audiological evaluation, behavioral central auditory processing (CAP) tests {Speech in Noise Test, Auditory Fusion Test and Auditory memory Tests}. In addition, cortical auditory evoked potentials (CAEPs) were conducted. Results: The migraine patients group had decreased speech discrimination in noise, poorer temporal processing and auditory memory when compared to their non migrainous peers. Lower MMSE and SDMT scores as well as delayed latencies of CAEPs were found in the migranous group. Patients with lower MMSE scores had poorer behavioral CAP scores and delayed CAEPs latenciesPatients with longer disease duration had lower MMSE scores. No correlations were observed between MMSE, SDMT, CAP scores and CAEPs latencies and migraine attacks severity or frequency. Conclusions: Migraine has deteriorating effect on the CAP abilities and cognitive functions. Recommendations: Early detection of these complications is important to prevent more central and cognitive deterioration. More studies should be directed to avoid such complications and how to be avoided

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