Thesis (M.Sc.) - Cairo University - Faculty of Physical Therapy - Department of Basic Science

Background: Obesity is a growing global health concern, with a rapid increase. The regulation of appetite and energy intake is influenced by gut hormones. Leptin is peptide hormones with adipostatic and orexigenic effect. Leptin is secreted by fat tissues which results in reduced food intake and increased energy expenditure. Obesity is often associated with high leptin levels and exogenous leptin resistance. Purpose: to investigate the effect of sex difference on total leptin exists after resistance exercise program in central obese subjects. Methods: This study was conducted on 12 central obese volunteer subjects. Patients were subdivided according to gender difference into 2 groups (group A: 6 female and group B: 6 male), each group received resistance exercise program, (14 exercises, 3 times/ week) for 14 week with low calorie diet of 1000 to 1200 kcal/ d. Concentrations of leptin, lactate and HOMA IR were measured at the beginning of the study and just immediately after treatment protocol.. Results: The results showed that the resistance exercise training resulted in a significant decrease in leptin regarding male group more than female (p < 0.01).Conclusion: Resistance exercise with low calorie diet decreased body weight and plasma leptin level which decreased in male group better than female group

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