Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology

Background: Malnutrition is an impor1ant problem in cancer patients. TIle study aimed to assess the nutritional stams of hospitalized patients with stomach, colorectal, and hepatic malignancies and relate the nutritional stams to different sociodemographic, clinicopathological characteristics, and survival. Methods:This cohor1 study included 298 patients (85 liver, 93 stomach, and 120 colorectal cancers) enrolled during the period from JanualY 2018 to September 2019. The instmments of this study consisted of Socio-demographic, clinicopathological characteristics, the Mini Nutritional Assessment (MNA) questionnaire, calculation of PNI score, and calculation of overall and progression-free survival after one year. Results: According to the :MNA score, malnutrition was found in 39.6% of all patients; 49.5% of the stomach, 39.2% of colorectal, and 29.4% of liver cancer patients. The independent factors that significantly predict nutritional status were nunor type (OR: 3.4: 95%CI: 1.6-7.1 - stomach versus liver) and (OR: 1.8, 95%CI: 0.9-3.6 - colorectal versus liver), psychological stams (OR: 3.8: 95%CI: 2.1 -6.8), performance status (OR: 5.6: 95%CI: 1.8-1 7.9), and smoking (OR: 1.9: 95%CI: 1.1-3.4). Stomach cancer patients had significantly worse PFS than liver and colorectal cancers (p=O.Oll and <0.001 , respectively). The independent factors that significantly affecting PFS were the nunor type and treatment (either radical or palliative). Colorectal cancer cases had better overall survival than liver and stomach cancer (p<O.OOI for both).TIle independent factors that significantly affect OS were the perfonnance stanis, nunor type, nutritional stams (using :MNA score), and treatment modality

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