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Assessment of tissue level of interleukin 9 in psoriasis and vitiligo / Nesma Ali Mohammed Salem ; Supervised Sara Bahaa Eldin , Aya Mohamed Fahim , Olfat Shaker

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Nesma Ali Mohammed Salem , 2020Description: 117 P . : charts ,facsmilies ; 25cmOther title:
  • تقييم مستوى الأنسجة من الإنترلوكين 9 فى الصدفية والبهاق [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology Summary: Background: Psoriasis is a chronic, inflammatory, T-cell-mediated autoimmune disease. Vitiligo is an acquired depigmentary disorder that occurs due to loss of functional melanocytes from the epidermis. Interleukin (IL)-9 is a T cell-derived cytokine. There is a link between the expression and action of IL-9 and pro-inflammatory cytokines, suggesting a possible association with the pathogenesis of autoimmune diseases. Aim: To measure the tissue levels of IL-9 in psoriasis and vitiligo patients in comparison to controls, in order to shed more light on the previously suggested role of IL-9 in psoriasis and investigate its possible role in vitiligo. Patients and methods: This study included 30 psoriasis patients, 30 vitiligo patients and 30 age and sex matched healthy controls. A skin biopsy was taken from all participants, for evaluation of tissue IL-9 levels by enzyme linked immunosorbent assay (ELISA). Results: Tissue IL-9 was significantly higher in psoriasis and vitiligo patients than controls (p=0.013 and <0.001 respectively). In addition, it was significantly higher in vitiligo than psoriasis patients (p=0.004). Conclusion: The present study suggests a possible role for IL-9 the pathogenesis of psoriasis and vitiligo through documenting significantly higher tissue levels in patients than controls
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.M.Sc.2020.Ne.A (Browse shelf(Opens below)) Not for loan 01010110082246000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.M.Sc.2020.Ne.A (Browse shelf(Opens below)) 82246.CD Not for loan 01020110082246000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology

Background: Psoriasis is a chronic, inflammatory, T-cell-mediated autoimmune disease. Vitiligo is an acquired depigmentary disorder that occurs due to loss of functional melanocytes from the epidermis. Interleukin (IL)-9 is a T cell-derived cytokine. There is a link between the expression and action of IL-9 and pro-inflammatory cytokines, suggesting a possible association with the pathogenesis of autoimmune diseases. Aim: To measure the tissue levels of IL-9 in psoriasis and vitiligo patients in comparison to controls, in order to shed more light on the previously suggested role of IL-9 in psoriasis and investigate its possible role in vitiligo. Patients and methods: This study included 30 psoriasis patients, 30 vitiligo patients and 30 age and sex matched healthy controls. A skin biopsy was taken from all participants, for evaluation of tissue IL-9 levels by enzyme linked immunosorbent assay (ELISA). Results: Tissue IL-9 was significantly higher in psoriasis and vitiligo patients than controls (p=0.013 and <0.001 respectively). In addition, it was significantly higher in vitiligo than psoriasis patients (p=0.004). Conclusion: The present study suggests a possible role for IL-9 the pathogenesis of psoriasis and vitiligo through documenting significantly higher tissue levels in patients than controls

Issued also as CD

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