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Zinc level in pediatric critical illness / Badr Ali Nosehy Elshamy ; Supervised Bassant Salah Meligy , Mona Mohey Eldin Abdelhahaleem , Elshimaa Salah Ahmed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Badr Ali Nosehy Elshamy , 2020Description: 76 P. : charts , facimiles ; 25cmOther title:
  • مستوى الزنك فى الأمراض الحرجة للأطفال [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Summary: Background: In critically ill patients, there are reduced stores of antioxidants, which are associated with increased organ failure and even higher mortality. Trace elements, especially zinc (Zn) and selenium, are the cornerstone of the antioxidant defense in acute systemic inflammatory response syndrome. The aim of our study is to detect the serum level of zinc as important immunomodulator in critically ill children and to investigate the relationship between Zn and the severity of illness, Sepsis and Mortality.Patient and Methods: The study was conducted on 50 critically ill children within 72 hours of intensive care unit admission with PRISMIII score more than 5, and 50 children of intensive care unit admissions as controls with PRISMIII score less than 5. Blood samples were collected from the two groups for zinc level measurement. Results: The study yielded the following results: Zn level was found to be decreased in critically ill children compared to control group (P value<.0001), and these levels were inversely correlated with pediatric logistic mortality scores. Zinc level was decreased in patients with sepsis and in patients with multiple organ failure (P value<.0001). Conclusion: The study concludes: zinc supplementation is important for a critically ill children and its deficiency might play role in the pathogenesis of severe sepsis
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2020.Ba.Z (Browse shelf(Opens below)) Not for loan 01010110082302000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2020.Ba.Z (Browse shelf(Opens below)) 82302.CD Not for loan 01020110082302000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background: In critically ill patients, there are reduced stores of antioxidants, which are associated with increased organ failure and even higher mortality. Trace elements, especially zinc (Zn) and selenium, are the cornerstone of the antioxidant defense in acute systemic inflammatory response syndrome. The aim of our study is to detect the serum level of zinc as important immunomodulator in critically ill children and to investigate the relationship between Zn and the severity of illness, Sepsis and Mortality.Patient and Methods: The study was conducted on 50 critically ill children within 72 hours of intensive care unit admission with PRISMIII score more than 5, and 50 children of intensive care unit admissions as controls with PRISMIII score less than 5. Blood samples were collected from the two groups for zinc level measurement. Results: The study yielded the following results: Zn level was found to be decreased in critically ill children compared to control group (P value<.0001), and these levels were inversely correlated with pediatric logistic mortality scores. Zinc level was decreased in patients with sepsis and in patients with multiple organ failure (P value<.0001). Conclusion: The study concludes: zinc supplementation is important for a critically ill children and its deficiency might play role in the pathogenesis of severe sepsis

Issued also as CD

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