Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dantal Medicine - Department of Periodontology

The purpose of this study was to evaluate the gain in clinical attachment and bone levels after treatment of the intra-bony defects by minimally invasive surgical technique when compared to open flap debridement. This study was carried out on patients attending the outpatient clinic of Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Medicine, Cairo University. The design of this study was a randomized controlled trial (RCT), parallel groups with 1:1 allocation ratio and equivalence framework. Double-blinded (the patients and radiographic assessors of results were blinded to the type of the periodontal surgery. Seven healthy individuals (3 Males, 4 females) with twenty two deep periodontal intra-bony defects were included in the study which satisfied for the eligibility criteria and completed follow up period. Intra-bony defects were randomly distributed in both groups 11 defect/per group with a mean age 33.64 for MIST group and 32.27 for (OFD) group. Each patient had preoperative and postoperative standardized periapical radiograph and measurement of periodontal parameters by a blinded examiner. After completion of phase 1 therapy, the patients were randomly assigned into 2 groups. In the test group, the patients were treated with minimally invasive periodontal surgeries whether simplified r modified papilla preservation flaps, while the control group patients were treated with the conventional open flap debridement. The results of the study showed that form baseline - 3 and baseline - 6 months postoperatively, there was a statistically significant difference in CAL gain, PD reduction within both the groups and there was no significant difference between both the groups at any time intervals. No statistical significant increase in gingival recession was recorded in both groups, with no statistical significant difference between both groups

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