Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology

Introduction: Extracranial germ cell tumors are categorized as rare pediatric tumors. Childhood germ cell tumors (GCTs) are an assorted group of malignant and benign neoplasms that vary with respect to their clinical presentation, histopathology, and biologic characteristics, but are all believed to originate from primordial germ cells. Patient and methods: Among fifty eight eligible patients with extracranial germ cell tumor enroled from June 2011 to June 2017 who were treated according to Children{u2019}s Oncology Group (COG) protocol AGCT0132 which divided pediatric patients with germ cell tumors into three categories: low, intermediate, and high risk groups. Results: The 3- years overall survival (OS) was 86.2% with a median follow up period of 38.3 months (range from 0.3-96.7months) and 3-years event free survival (EFS) was 82.8% with median 36.1months (range from 0.1- 94.8months). The independent factor that significantly affect the overall survival was site of the primary [(gonadal vs extragonadal) (HR: 14.481, 95% CI: 1.761-119.063, p= 0. 013)] and pathological subtypes [(teratoma vs others) (HR: 8.210, 95% CI: 1.001-67.365, p=0.049)] and the independent factor that significantly affect the event-free survival were site of the primary [(gonadal vs extragonadal) (HR: 3.979, 95% CI: 1.027-15.406, p= 0. 046)] and pathological subtypes [(teratoma vs others) (HR: 6.508, 95% CI: 1.155-53.486, p=0.036)]

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