header
Image from OpenLibrary

Studies on hypothyroidism in dogs / Noha Mahmoud Ryad Radwan ; Supervised Ibrahim Abdelsattar Saleh , NohaYousef Mohamed Salem , Eman Shawky Ramadan

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Noha Mahmoud Ryad Radwan , 2020Description: 111 P. : photoghrphs ; 25cmOther title:
  • دراسات عن قصور الغده الدرقيه فى الكلاب [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Internal Medicine and Infectious Diseases Summary: Background: Hypothyroidism is the most recorded endocrinopathy in dogs. Its diagnosis is not always straightforward. Thyroid hormone levels affected by drugs mostly glucocorticoids and non-thyroidal illness. Reports suggest that the oxidative process may be present in hypothyroid patients. Aim: investigate canine hypothyroidism in terms of clinical, haemato-biochemical, thyroid panel alterations and evaluate response to treatment in hypothyroid dogs, evaluate the influence of dexamethasone parenterally (IM) on hematology, biochemistry, thyroid function in healthy dogs, Study oxidative stress alterations in both hypothyroid and euthyroid dogs, show the effect of levothyroxine administration on clinical recovery in generalized demodicosis with euthyroid syndrome.Methods: 1) multicenter study enrolled 220 dogs with dermatologic signs, of which 40 dogs with signs of hypothyroidism were subjected to initial screening using TT4. Only 15 dogs showed decrease in TT4 and were subjected to further investigation and eight normal dogs were enrolled as control, 2)other Ten mongrel dogs used, each dog received dexamethasone (0.1 mg/kg once daily) for 7 days then on an alternate day for 14 days. 3) Another thirteen dogs (six hypothyroid dogs and seven euthyroid dogs) enrolled in a study, blood samples were taken for evaluation of FT4, TT4, TSH, Cholesterol, triglycerides, ALP, (MDA), and (TAC), 4) 15 dogs used 10 infected with demodicosis& 5 control, thyroid panel evaluated in all dogs & levothyroxine added to the protocol of treatment. Results: first study showed incidence of hypothyroidism was 6.8 percent. Significant decrease in RBCs, PCV, TT4 and FT4 with non-significant increase in TSH and cholesterol were recorded in hypothyroid patients. Treatment with levothyroxine caused thyroid hormones to return to normal range. Second study after dexamethasone administration There was elevation in ALT and ALP. Total T4 decreased significantly at day 7 and day 21. Free T4 showed a non-significant decrease at day 7 and day 21 compared to day 0 values, TSH showed a non-significant decrease at day 7
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.09.M.Sc.2020.No.S (Browse shelf(Opens below)) Not for loan 01010110082746000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.09.M.Sc.2020.No.S (Browse shelf(Opens below)) 82746.CD Not for loan 01020110082746000

Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Internal Medicine and Infectious Diseases

Background: Hypothyroidism is the most recorded endocrinopathy in dogs. Its diagnosis is not always straightforward. Thyroid hormone levels affected by drugs mostly glucocorticoids and non-thyroidal illness. Reports suggest that the oxidative process may be present in hypothyroid patients. Aim: investigate canine hypothyroidism in terms of clinical, haemato-biochemical, thyroid panel alterations and evaluate response to treatment in hypothyroid dogs, evaluate the influence of dexamethasone parenterally (IM) on hematology, biochemistry, thyroid function in healthy dogs, Study oxidative stress alterations in both hypothyroid and euthyroid dogs, show the effect of levothyroxine administration on clinical recovery in generalized demodicosis with euthyroid syndrome.Methods: 1) multicenter study enrolled 220 dogs with dermatologic signs, of which 40 dogs with signs of hypothyroidism were subjected to initial screening using TT4. Only 15 dogs showed decrease in TT4 and were subjected to further investigation and eight normal dogs were enrolled as control, 2)other Ten mongrel dogs used, each dog received dexamethasone (0.1 mg/kg once daily) for 7 days then on an alternate day for 14 days. 3) Another thirteen dogs (six hypothyroid dogs and seven euthyroid dogs) enrolled in a study, blood samples were taken for evaluation of FT4, TT4, TSH, Cholesterol, triglycerides, ALP, (MDA), and (TAC), 4) 15 dogs used 10 infected with demodicosis& 5 control, thyroid panel evaluated in all dogs & levothyroxine added to the protocol of treatment. Results: first study showed incidence of hypothyroidism was 6.8 percent. Significant decrease in RBCs, PCV, TT4 and FT4 with non-significant increase in TSH and cholesterol were recorded in hypothyroid patients. Treatment with levothyroxine caused thyroid hormones to return to normal range. Second study after dexamethasone administration There was elevation in ALT and ALP. Total T4 decreased significantly at day 7 and day 21. Free T4 showed a non-significant decrease at day 7 and day 21 compared to day 0 values, TSH showed a non-significant decrease at day 7

Issued also as CD

There are no comments on this title.

to post a comment.