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Study of levels of sex hormone binding globulin in non alcoholic fat / Mona Elsayed Mohammed ; Supervised Ula Mabid Aljarhi , Dina Hesham Ahmed , Shaimaa Ahmed Fathy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mona Elsayed Mohammed , 2020Description: 118 P. : charts , facsimiles ; 25cmOther title:
  • دراسة مستوى الجلوبين المرتبط بالهرمونات الجنسية في السيروم فى مرضى الكبد الدهنى غيرالكحولى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine Summary: Background: Nonalcoholic fatty liver disease (NAFLD) is the fastest growing cause of chronic liver disease, with a 25% worldwide prevalence. Low serum level of sex hormone binding globulin (SHBG) is strongly associated with components of the metabolic syndrome and NAFLD, with a possible role in pathogenesis. Key words: NAFLD, SHBG, metabolic syndrome, NAFLD fibrosis score. Aim of the work: to investigate the relationship between SHBG and the degree of liver fibrosis in female subjects with NAFLD. Methods: The study included 60 consecutive female patients with NAFLD and 30 age-matched female healthy subjects. Components of the metabolic syndrome according to ATP III, NAFLD fibrosis score and SHBG level were done to all subjects.Results: SHBG was found to have a significant positive correlation with the NAFLD fibrosis score. It was found to be an efficient positive predictor of severe fibrosis in female NAFLD patients at a cut-off level > 10 ng/ml, with a high specificity and modest sensitivity. Conclusions: SHBG levels increase with liver fibrosis in female patients with NAFLD. SHBG is a potential non-invasive marker of liver fibrosis in such patients
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2020.Mo.S (Browse shelf(Opens below)) Not for loan 01010110082765000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2020.Mo.S (Browse shelf(Opens below)) 82765.CD Not for loan 01020110082765000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Background: Nonalcoholic fatty liver disease (NAFLD) is the fastest growing cause of chronic liver disease, with a 25% worldwide prevalence. Low serum level of sex hormone binding globulin (SHBG) is strongly associated with components of the metabolic syndrome and NAFLD, with a possible role in pathogenesis. Key words: NAFLD, SHBG, metabolic syndrome, NAFLD fibrosis score. Aim of the work: to investigate the relationship between SHBG and the degree of liver fibrosis in female subjects with NAFLD. Methods: The study included 60 consecutive female patients with NAFLD and 30 age-matched female healthy subjects. Components of the metabolic syndrome according to ATP III, NAFLD fibrosis score and SHBG level were done to all subjects.Results: SHBG was found to have a significant positive correlation with the NAFLD fibrosis score. It was found to be an efficient positive predictor of severe fibrosis in female NAFLD patients at a cut-off level > 10 ng/ml, with a high specificity and modest sensitivity. Conclusions: SHBG levels increase with liver fibrosis in female patients with NAFLD. SHBG is a potential non-invasive marker of liver fibrosis in such patients

Issued also as CD

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