Correlation between glycated hemoglobin (HBA1c), glycated albumin levels and cardiovascular risk factors in pre-diabetic metabolic syndrome patients / Mennatallah Mostafa Abdelnaby ; Supervised Sahar Saif Elnasr Elwakil , Laila Ahmed Rashed , Shaimaa Ahmed Fathy

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Background: The metabolic syndrome is a major and escalating public-health problem. It is a predisposing factor of cardio vascular disease. Cardiovascular disease is a leading cause of morbidity and mortality all over the world. Studies have shown that subjects having pre-diabetes are also at a high risk for CVD. Pre-diabetes refers to an intermediate stage between normal glucose tolerance and overt T2DM, Glycated albumin reflects short-term (2{u2013}3 weeks) mean glycemic levels. GA values are not affected by changes in erythrocyte lifespan which invalidate HbA1c measurements in the diagnosis of diabetes. Objectives: The aim of the study is to correlate between HbA1c, glycated albumin and cardiovascular risk factors in prediabetic metabolic syndrome patients. Methods: One hundred pre-diabetic patients diagnosed as metabolic syndrome were subjected to full history taking and examination, full anthropometric measurements, laboratory tests including: FBS, uric acid, HbA1c, lipid profile, glycated albumin levels, urea, creatinine and A/c ratio. Results: Our study showed that regarding anthropometric measures: weight is negatively correlated to glycated albumin (P value <0.001) but positively correlated to HbA1c level (P value <0.001). Waist circumference is negatively correlated to glycated albumin level (P value 0.003). But it positively correlated to HbA1c level (P value 0.01). Neck circumference is negatively correlated to glycated albumin level (P value <0.001) But positively correlated to HbA1c level (P value 0.016). Hip Circumference is negatively correlated to glycated albumin (P value 0.007)

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