Relation between fibrinogen level and overt hypothyroidism / Abdelrahman Sherif Sayed Ahmed Saleh ; Supervised Soad Elsayed Sultan , Heba Sharaf Eldeen , Fadia Moris Bolis

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Rationale: The hemostatic balance is a complex system where the delicate equilibrium is regulated by several factors including hormones.A variety of endocrine disorders have been reported to be associated with coagulation abnormalities, ranging from mild laboratory changes to clinically relevant thrombotic or bleeding manifestations. A kaleidoscope of coagulation disorders has been reported in patients with thyroid dysfunctions. Globally, these disorders involve both primary and secondary hemostasis and range from subclinical laboratory abnormalities to, more rarely, life-threatening hemorrhages or thrombotic events. Subclinical hypothyroidism and mild hypothyroidism have been reported as prothrombotic state.The mechanisms involved in these observations are also not conformed. Overt hypothyroidism is more associated with a hypocoagulable state. Decreased platelet count, aggregation and agglutination, von Willebrand factor antigen and activity, several coagulation factors such as factor VIII, IX, XI, VII, and plasminogen activator-1 are detected in overt hypothyroidism. Increased fibrinogen has been detected in subclinical hypothyroidism rendering a tendency towards a hypercoagulability state. Increased factor VII and its activity, and plasminogen activator inhibitor-1 are among several findings contributing to a prothrombotic state in subclinical hypothyroidism

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