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Evaluating the effect of desflurane versus sevoflurane withrecent biomarkers of renal and hepatic function in laparoscopic cholecystecomy patients / Mohammad Ahmad Saleh Bashar ; Supervised Mohamed Hafez Elsaied Hafez , Sohaila Hussein Omar , Azza Saleh Radwan

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohammad Ahmad Saleh Bashar , 2020Description: 141 P. : charts , facsimiles ; 25cmOther title:
  • تحديثات فى تقييم أثر الديسفلورين والسيفوفلورين على وظائف الكبد والكلى فى مرضى استئصال المرارة بالمنظار [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia Summary: Background: Exposure to inhalational anesthetics is associated with hepatic and renal changes. aim: To compare sevoflurane (S) versus desflurane (D) with more sensitive and specific biomarkers of hepatic and renal functions in patients undergoing elective laparoscopic cholecystectomy. patients and methods: A prospective randomized study with 70 patients (D, n = 35 and S, n = 35). Neutrophil Gelatinase Associated Lipocalin, Cystatin-C, Arginase, liver (AST, ALT) and kidney function tests (BUN and creatinine) were assayed.results: High serum NGAL levels suggest the possibility of subclinical renal injury in the desflurane group, but with no renal clinical adverse effects.The specific biomarkers showed early elevations at 1 hour postoperatively for cystatin and 1 to 6 hours postoperatively with arginase in both groups, with no adverse clinical renal or liver effects. conclusion:This study confirmed that sevoflurane and desflurane provide safe anesthetic profiles regarding renal and hepatic integrity during limited duration laparoscopic procedures. Sevoflurane and desflurane had no adverse clinical effects in these patients undergoing laparoscopic cholecystecomy. Wide scale studies comprising larger numbers of patients should be performed to assess the microscopic effects on hepatic and renal integrity using sevoflurane and desflurane during longer periods of exposure to pneumoperitoneum and volatile anesthetics
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.01.Ph.D.2020.Mo.E (Browse shelf(Opens below)) Not for loan 01010110083054000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.01.Ph.D.2020.Mo.E (Browse shelf(Opens below)) 83054.CD Not for loan 01020110083054000
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Cai01.11.01.Ph.D.2020.Ka.S The success rate of ultrasound guided sacroiliac joint steroid injections in sacroiliitis. are we getting better? / Cai01.11.01.Ph.D.2020.Ka.S The success rate of ultrasound guided sacroiliac joint steroid injections in sacroiliitis. are we getting better? / Cai01.11.01.Ph.D.2020.Mo.E Evaluating the effect of desflurane versus sevoflurane withrecent biomarkers of renal and hepatic function in laparoscopic cholecystecomy patients / Cai01.11.01.Ph.D.2020.Mo.E Evaluating the effect of desflurane versus sevoflurane withrecent biomarkers of renal and hepatic function in laparoscopic cholecystecomy patients / Cai01.11.01.Ph.D.2020.Mu.I Intraoperative motor evoked potential monitoring of facial nerve in patients undergoing cerebellopontine angle tumour resection using partial versus no neuromuscular block / Cai01.11.01.Ph.D.2020.Mu.I Intraoperative motor evoked potential monitoring of facial nerve in patients undergoing cerebellopontine angle tumour resection using partial versus no neuromuscular block / Cai01.11.01.Ph.D.2020.Ne.I Impact of desflurane versus sevoflurane on coagulation in radical cystectomy patients : A randomized clinical study /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia

Background: Exposure to inhalational anesthetics is associated with hepatic and renal changes. aim: To compare sevoflurane (S) versus desflurane (D) with more sensitive and specific biomarkers of hepatic and renal functions in patients undergoing elective laparoscopic cholecystectomy. patients and methods: A prospective randomized study with 70 patients (D, n = 35 and S, n = 35). Neutrophil Gelatinase Associated Lipocalin, Cystatin-C, Arginase, liver (AST, ALT) and kidney function tests (BUN and creatinine) were assayed.results: High serum NGAL levels suggest the possibility of subclinical renal injury in the desflurane group, but with no renal clinical adverse effects.The specific biomarkers showed early elevations at 1 hour postoperatively for cystatin and 1 to 6 hours postoperatively with arginase in both groups, with no adverse clinical renal or liver effects. conclusion:This study confirmed that sevoflurane and desflurane provide safe anesthetic profiles regarding renal and hepatic integrity during limited duration laparoscopic procedures. Sevoflurane and desflurane had no adverse clinical effects in these patients undergoing laparoscopic cholecystecomy. Wide scale studies comprising larger numbers of patients should be performed to assess the microscopic effects on hepatic and renal integrity using sevoflurane and desflurane during longer periods of exposure to pneumoperitoneum and volatile anesthetics

Issued also as CD

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