Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Inorganic Chemistry

Because of the beneficial therapeutic functions of CO, despite its toxicity, CO releasing molecules (CORMs) were discovered as an alternative route for CO administration, to overcome the potential threat of CO intake. In this work two series of photoactivatable CO releasing bromo tricarbonyl manganese(I) complexes featuring N,N{u2019}-bidentate Schiff base ligands bearing electron donating or electron withdrawing group, with the general formula [MnBr(CO)₃SB] (SB= N,N{u2019}-benzylidinethane-1,2-diamine) for the first series, and [MnBr(CO)₃L] (L= quinoline and pyridine Schiff base derivatives) for the second one, were synthesized and characterized. The influence of the nature of the substituent on the stability of the compounds in the dark and the photophysical properties upon illumination was investigated in both series. In the first series, the effect of the position of the substituent was investigated, however, in the second one, the effect of the extended conjugation of the heterocyclic ring on the photophysical properties was investigated.The combined UV/Vis and IR data clearly revealed that the aerated solutions of the studied PhotoCORMs in either coordinating or noncoordinating solvents are dark stable, and the fluctuations occurred during the incubation, especially in the case of the electron withdrawing derivatives, may be attributed to exchange of the axial bromo ligand with coordinating solvent molecules

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