Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of General Surgery

The effects of liver I / R injury are still a major concern during extensive liver resections in which clamping of the afferent vessels are necessary to minimize blood loss Although extensive research has been conducted over the past decades to explore the mechanisms involved in I / R injury , these complex mechanisms , involving several pathways , are not yet fully understood Animal studies are still an important part of current research , especially when mechanistic issues are investigatedThe decrease in intra - operative and postoperative complications has improved the outcome of major liver surgery over the last decadesThe reduction of intra - operative blood loss by clamping the afferent vessels to the liver , with or without clamping of the supra - hepatic and infra - hepatic caval vein , significantly contributed to this achievement A further decrease in postoperative morbidity can be accomplished by reducing procedure related liver injury , such as I / R injuryThe objective of this study was to decrease liver I / R injury by means of a decrease in core liver temperature of 10?C or 18?C , achieved by in situ hypothermic perfusion of the liver during ischemia using three types of different perfusion solutions

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