Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pharmacology

Background: Diabetic gastroparesis is a component of autonomic neuropathy resulting from long-standing poorly controlled diabetes. It is a serious complication of diabetes resulting in delayed gastric emptying with associated upper gastrointestinal symptoms in the absence of any mechanical obstruction. Delayed gastric emptying may result in uncontrolled blood glucose, bad nutrition and dehydration which result in poor quality of life. Objectives: The present experimental study was designed to evaluate the therapeutic effects of mosapride and levosulpiride on improving gastric emptying in type 2 diabetes while regulating glycemic levels.Materials and methods: Adult albino rats weighing (150-200g) were used. Type 2 diabetes was induced by streptozotocin-nicotinamide model. Treatment was started orally daily after four weeks from onset of diabetes for 2 weeks. metformin (100mg/kg), mosapride (3mg/kg), levosulpiride (5mg/kg), metformin and mosapride, metformin and levosulpiride were administered orally daily for 14 days. Blood samples were withdrawn from rats{u2019} tail veins after rise of blood glucose and at the end of the experiment for measuring serum glucose level, insulin level and GLP-1. In addition rats were taken for measuring intestinal transit. Gastric motility study was done using isolated rat fundus and pylorus strips preparations from all groups.Results: Induction of type 2 diabetes in rats resulted in significant increase of serum glucose levels and significant reduction of insulin and GLP-1 levels. Intestinal transit was significantly reduced

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