Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Chest Diseases and Tuberculosis

Rational & Background: It is well known that there is increased prevelance of OSA among COPD patients (overlap syndrome).Therefore many researches studied the prevelance and outcome of coexistence of OSA in COPD patients . Aim of the work: Is to study the clinical characteristics of overlap syndrome. Subjects and methods: This study was conducted in Chest department, Kasr Al Ainy hospital, Cairo University .It included sixty patients diagnosed as COPD. All patients were subjected to full history taking, clinical examination, blood tests ( cholesterol, triglycerides, LDL and HDL), pulmonary function test ,body measurements (BMI, neck circumference), the Epworth Sleepiness scale(ESS),STOP BANG score and Polysomnography (PSG). Results: The results of the study showed that overlap syndrome were more in males than females, it was found that males represent (66.7%) and females (33.3%)respectively ,the prevelance of overlap syndrome was 70%among our studied patients .The mean of BMI of overlap syndrome patients was 41.97 kg/m2 and most of them were class 3 obesity(BMI>40 kg/m2),the mean of the neck circumference of overlap syndrome patients was 45.3 cm. There was a significant positive correlation between airway obstruction and severity in OSA (p-value < 0.001),Diabetes was more prevelant in overlap syndrome patients (p value 0.39) while cardiac arrhythmia was more prevelant in COPD patients (p value 0.23). Conclusion and recommendation: There is increased prevelance of OSA among COPD patients.We recommend doing PSG as a routine examination in COPD patients to detect occurrence of OSA in those patients

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