Analytical study of some selected compounds containing nitrogen / Aya Ahmed Mohamed ; Supervised Nadia Mohamed Mostafa , Nesrine Talaat Lamie , Basma Mohamed Eltanany

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

This work is concerned with the quantitative determination of some mixtures of drugs containing nitrogen including; Salmeterol xinafoate (SAL) in its mixture with Fluticasone propionate (FLU), Ephedrine hydrochloride (EPH) in its mixture with Naphazoline nitrate and Parabens. In this thesis; different analytical techniques were adopted, namely, spectrophotometric, UV-chemometric and liquid chromatographic methods for the determination of the previously mentioned compounds in their pure powder, laboratory prepared mixtures and dosage forms. In part I; General introduction of Nitrogen containing compounds. In part IЇ; General introduction and literature review of SAL and FLU were described. This part described also the quantitative determination of SAL and FLU in their combination either in pure form or dosage form using spectrophotometry including four methods (First derivative (1D), ratio difference (RD), the first derivative of the ratio spectra (1DD) and mean centering of ratio spectra (MC)), TLC-Densitometry and HPLC methods. In part IIЇ; General introduction and literature review of EPH and NAPH were described. Then different analytical methods were described for the determination of the studied drugs in their combination either in pure form or dosage form including UV-Chemometry, TLC-Densitometry, HPLC methods

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