Anti-inflammatory, antioxidant and antimutagenic effects of Senna and Fennel extracts on human blood cultures exposed to Þ-radiation / Dina Kamel Abdelfattah Ibrahim ; Supervised Alyaa Ahmed Farid Ahmed , Mona Mohamed Elamir , Mahmoud Mohamed Ahmed

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Dina Kamel Abdelfattah Ibrahim

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TextLanguage: English Publication details: Cairo : Dina Kamel Abdelfattah Ibrahim , 2021Description: 79 P . : charts , facsmilies ; 25cmOther title:

التأثيرات المضادة للإلتهاب و الأكسدة و الطفرات الوراثية لمستخلص نبات السينا و الشمر فى مزارع دم الإنسان المعرضة لأشعة جاما [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology Summary: The present work aimed to examine the antioxidant, anti-inflammatory and anti-mutagenic effects of senna and fennel via synergetic mechanisms against deleterious effects of gamma radiation exposure. Cytogenetic, biochemical and immunological investigations were evaluated in human blood lymphocyte cultures. Samples were divided into Group 1: control samples, Group 2: irradiated samples with 3Gy Þ-irradiation (Radiation- gp) , Group 3: treated samples with calcium sennosides (senna- gp), Group 4: treated samples with fennel seed extract (fennel- gp), Group 5: treated samples with mixture of calcium sennosides and fennel seed extract (SF- gp), Group 6: irradiated treated samples with calcium sennosides (RS-gp), Group 7: irradiated treated samples with fennel seed extract (RF-gp) and Group 8: irradiated treated samples with mixture of calcium sennosides and fennel seed extract (RSFgp). The results revealed that radiation exposure caused an increment in numbers of micronucleus (MN), nucleoplasmic bridges (NPBs), bi-, and multinucleated cells. Biochemical results revealed a decrease in levels of superoxide dismutase (SOD) and Catalase enzymes and an increase in Lactate Dehydrogenase (LDH) level after irradiation. Levels of cytokines (IL-1Ý, IL-6, IL-8 and TNF- Ü) were significantly increased in irradiated group. Calcium sennosides and fennel seed extract mixture treatment after radiation exposure succeeded in returning cytokines and anti-oxidant enzymes levels to their normal levels as compared to control. Also, group 8 (RSF- gp) showed a marvelous improvement in numbers of MN and NPBs frequencies. These results indicate that combination between Calcium sennosides as a free radical scavenger and fennel as an apoptic inducer can be used as a treatment against oxidative and inflammation effects of ionizing radiation

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.21.Ph.D.2021.Di.A (Browse shelf(Opens below))		Not for loan		01010110083305000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.21.Ph.D.2021.Di.A (Browse shelf(Opens below))	83305.CD	Not for loan		01020110083305000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology

The present work aimed to examine the antioxidant, anti-inflammatory and anti-mutagenic effects of senna and fennel via synergetic mechanisms against deleterious effects of gamma radiation exposure. Cytogenetic, biochemical and immunological investigations were evaluated in human blood lymphocyte cultures. Samples were divided into Group 1: control samples, Group 2: irradiated samples with 3Gy Þ-irradiation (Radiation- gp) , Group 3: treated samples with calcium sennosides (senna- gp), Group 4: treated samples with fennel seed extract (fennel- gp), Group 5: treated samples with mixture of calcium sennosides and fennel seed extract (SF- gp), Group 6: irradiated treated samples with calcium sennosides (RS-gp), Group 7: irradiated treated samples with fennel seed extract (RF-gp) and Group 8: irradiated treated samples with mixture of calcium sennosides and fennel seed extract (RSFgp). The results revealed that radiation exposure caused an increment in numbers of micronucleus (MN), nucleoplasmic bridges (NPBs), bi-, and multinucleated cells. Biochemical results revealed a decrease in levels of superoxide dismutase (SOD) and Catalase enzymes and an increase in Lactate Dehydrogenase (LDH) level after irradiation. Levels of cytokines (IL-1Ý, IL-6, IL-8 and TNF- Ü) were significantly increased in irradiated group. Calcium sennosides and fennel seed extract mixture treatment after radiation exposure succeeded in returning cytokines and anti-oxidant enzymes levels to their normal levels as compared to control. Also, group 8 (RSF- gp) showed a marvelous improvement in numbers of MN and NPBs frequencies. These results indicate that combination between Calcium sennosides as a free radical scavenger and fennel as an apoptic inducer can be used as a treatment against oxidative and inflammation effects of ionizing radiation

Issued also as CD

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