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Risk of alzheimer{u2018}s disease in ovariectomized rats and possible preventive effect of incretin-based therapy and exercise / Samah Mahmoud Abdelaal Abdelaal Kholief ; Supervised Samah Mohamed Ahmed Alattar , Sarah Mahmoud Gamal , Mira Farouk Youssef

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Samah Mahmoud Abdelaal Abdelaal Kholief , 2020Description: 222 P. : charts , facsimiles ; 25cmOther title:
  • خطر الاصابة بمرض الالزهايمر فى الجرذان المستاصل لها المبايض وامكانية منع هذه الاصابة باستخدام الادوية المبنية على الانكريتين وممارسة الرياضة [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology Summary: Introduction: Alzheimer{u2018}s disease (AD) is one of the most common neurodegenerative disease and accounts for more than 80% of dementia cases worldwide in elderly people. It leads to progressive mental and behavioral, functional decline and progressive loss of the ability to learn. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million are 65 years old or more. It is expected that by 2050, one new case of AD will develop every 33 seconds, or nearly a million new cases per year, and the total estimated prevalence is expected to be 13.8 million. Spontaneous menopause which is the permanent cessation of menstruation caused by loss of ovarian function occurs at a mean age of 51{u2013}52 years. Many women complain of changes in their cognitive function during the menopause transition, with the majority reporting worsening of memory. Women may notice difficulty remembering names and other verbally told information. Incretins can be considered as {u2018}the intelligent hormones{u2018} and may hold the key to successfully treating the alarming rise in neurodegenerative disorders. Sitagliptin is one of dipeptidyl-peptidase DPP-4 inhibitors; DPP-4 is an enzyme that degrades incretin hormones. Physical exercise PE has many biological benefits. Among them, those linked to "neuroplasticity " are quite important. For this reason, PE may be considered as an enhancer environmental factor promoting neuroplasticity, reduces the risk of developing dementia, the level of deterioration in executive functions and improves the quality of life. Objectives: Here, we investigated the risk of Alzheimer{u2018}s disease in ovariectomized rats and the possibility of prevention of that risk using one of DPP-4 inhibitors (sitagliptin), physical exercise (PE) and combination of both.
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.30.M.Sc.2020.Sa.R (Browse shelf(Opens below)) Not for loan 01010110083344000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.30.M.Sc.2020.Sa.R (Browse shelf(Opens below)) 83344.CD Not for loan 01020110083344000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology

Introduction: Alzheimer{u2018}s disease (AD) is one of the most common neurodegenerative disease and accounts for more than 80% of dementia cases worldwide in elderly people. It leads to progressive mental and behavioral, functional decline and progressive loss of the ability to learn. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million are 65 years old or more. It is expected that by 2050, one new case of AD will develop every 33 seconds, or nearly a million new cases per year, and the total estimated prevalence is expected to be 13.8 million. Spontaneous menopause which is the permanent cessation of menstruation caused by loss of ovarian function occurs at a mean age of 51{u2013}52 years. Many women complain of changes in their cognitive function during the menopause transition, with the majority reporting worsening of memory. Women may notice difficulty remembering names and other verbally told information. Incretins can be considered as {u2018}the intelligent hormones{u2018} and may hold the key to successfully treating the alarming rise in neurodegenerative disorders. Sitagliptin is one of dipeptidyl-peptidase DPP-4 inhibitors; DPP-4 is an enzyme that degrades incretin hormones. Physical exercise PE has many biological benefits. Among them, those linked to "neuroplasticity " are quite important. For this reason, PE may be considered as an enhancer environmental factor promoting neuroplasticity, reduces the risk of developing dementia, the level of deterioration in executive functions and improves the quality of life. Objectives: Here, we investigated the risk of Alzheimer{u2018}s disease in ovariectomized rats and the possibility of prevention of that risk using one of DPP-4 inhibitors (sitagliptin), physical exercise (PE) and combination of both.

Issued also as CD

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