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Expression of B7-H1 in colorectal epithelial neoplasms : histopathological and immunohistochemical study / Merna Sobhy Yassa ; Supervised Hany Khattab , Hanan Soliman , Miran Atef

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Merna Sobhy Yassa , 2021Description: 174 P. : charts , facsimiles ; 25cmOther title:
  • تعبير بى7- اتش1 فى الأورام الطلائية للقولون والمستقيم : دراسة هستوباثولوجية وهستوكيميائية مناعية [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: Background: Colorectal carcinoma CRC is the third most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide and a leading cause of cancer related deaths. Conventional (tubular, tubulovillous and villous) adenomas are the most common neoplastic lesions occurring in the large intestine.Based on insight into immune system / cancer interactions, cancer immunotherapy strategies have been developed. Of these strategies, immune checkpoints regulators are among the most important. B7-H1 2programmed Death Ligand 1 (PD-L1)3 is one of the 2 ligands of Programmed Death-1 (PD-1); an important immune checkpoint regulator. Clinical trials using PD-L1 antibodies have shown efficacy in various cancers.Objectives: Detection of immunohistochemical (IHC) expression of B7-H1 by tumor cells (TC) and stromal tumor infiltrating lymphocytes (I) in colorectal adenocarcinoma, adenomatous polyp and ulcerative colitis and correlation of this expression with the clinico-pathologic parameters. Materials and methods: 53 cases (30 colorectal adenocarcinoma, 18 colorectal polyp and 5 ulcerative colitis). IHC expression of B7-H1 was investigated in tumor or epithelial cells (T- epithelial) and lymphocytes or stroma (I- stroma)
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.M.Sc.2021.Me.E (Browse shelf(Opens below)) Not for loan 01010110083403000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.M.Sc.2021.Me.E (Browse shelf(Opens below)) 83403.CD Not for loan 01020110083403000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology

Background: Colorectal carcinoma CRC is the third most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide and a leading cause of cancer related deaths. Conventional (tubular, tubulovillous and villous) adenomas are the most common neoplastic lesions occurring in the large intestine.Based on insight into immune system / cancer interactions, cancer immunotherapy strategies have been developed. Of these strategies, immune checkpoints regulators are among the most important. B7-H1 2programmed Death Ligand 1 (PD-L1)3 is one of the 2 ligands of Programmed Death-1 (PD-1); an important immune checkpoint regulator. Clinical trials using PD-L1 antibodies have shown efficacy in various cancers.Objectives: Detection of immunohistochemical (IHC) expression of B7-H1 by tumor cells (TC) and stromal tumor infiltrating lymphocytes (I) in colorectal adenocarcinoma, adenomatous polyp and ulcerative colitis and correlation of this expression with the clinico-pathologic parameters. Materials and methods: 53 cases (30 colorectal adenocarcinoma, 18 colorectal polyp and 5 ulcerative colitis). IHC expression of B7-H1 was investigated in tumor or epithelial cells (T- epithelial) and lymphocytes or stroma (I- stroma)

Issued also as CD

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