header
Image from OpenLibrary

Assessment of systemic vascular resistance in juvenile SLE patients and its impact on myocardial dysfunction / Rabab Fouad Hussien Abdelgawad ; Supervised Huda Marzok Mohammed , Engy Adel Mogahed , Antoine Fakhry Abdelmasseh

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rabab Fouad Hussien Abdelgawad , 2021Description: 127 P . : charts , facsmilies ; 25cmOther title:
  • تقيم المقارمة الوعائية الجهازية فى الاطفال المصابين بمرض الزئبة الحمراء وتاثيرها على اختلال عضلة القلب [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Summary: Background: Early diagnosis of myocardial dysfunction in patients with systemic lupus erythematosus (SLE) is crucial. Given the elevated cardiovascular risk in these patients, several markers of subclinical cardiovascular disease have been evaluated. Aim of work: To evaluate arterial stiffness and systemic vascular resistance (SVR) in pediatric patients with SLE using non-invasive electrical cardiometry (ICON). Moreover to assess its impact on the myocardial functions using echocardiography. Patients and methods: This cross sectional study included 40 patients with SLE and 40 age and sex matched healthy controls who were evaluated by standard echocardiogram and electrical cardiometry. Results: The mean age of the patients was 11.13 years. The mean duration of the SLE disease was 25.00 months. SLEDAI score ranged from 0 to 14 at the time of examination. By conventional, tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE), there was a statistically significant increased LVE/E and RVE/E in SLE patients than the controls, which indicate RV, LV diastolic dysfunction. Ejection fraction and LV global longitudinal strain (GLS) were significantly lower in SLE patients than the controls indicating LV systolic dysfunction. Regarding the results of Icon, there was a statistically significant increase in SVR in patients with SLE in comparison to controls. There was a significant affection in both systolic & diastolic functions in patients with higher disease activity done by the SLEDAI score. SVR was statistically higher in patients with higher disease activity. Conclusion: Children with SLE have a significant prevalence of both systolic and diastolic myocardial dysfunction as well as increased SVR. Therefor, these patients have an increased risk of cardiovascular events
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2021.Ra.A (Browse shelf(Opens below)) Not for loan 01010110083450000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2021.Ra.A (Browse shelf(Opens below)) 83450.CD Not for loan 01020110083450000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background: Early diagnosis of myocardial dysfunction in patients with systemic lupus erythematosus (SLE) is crucial. Given the elevated cardiovascular risk in these patients, several markers of subclinical cardiovascular disease have been evaluated. Aim of work: To evaluate arterial stiffness and systemic vascular resistance (SVR) in pediatric patients with SLE using non-invasive electrical cardiometry (ICON). Moreover to assess its impact on the myocardial functions using echocardiography. Patients and methods: This cross sectional study included 40 patients with SLE and 40 age and sex matched healthy controls who were evaluated by standard echocardiogram and electrical cardiometry. Results: The mean age of the patients was 11.13 years. The mean duration of the SLE disease was 25.00 months. SLEDAI score ranged from 0 to 14 at the time of examination. By conventional, tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE), there was a statistically significant increased LVE/E and RVE/E in SLE patients than the controls, which indicate RV, LV diastolic dysfunction. Ejection fraction and LV global longitudinal strain (GLS) were significantly lower in SLE patients than the controls indicating LV systolic dysfunction. Regarding the results of Icon, there was a statistically significant increase in SVR in patients with SLE in comparison to controls. There was a significant affection in both systolic & diastolic functions in patients with higher disease activity done by the SLEDAI score. SVR was statistically higher in patients with higher disease activity. Conclusion: Children with SLE have a significant prevalence of both systolic and diastolic myocardial dysfunction as well as increased SVR. Therefor, these patients have an increased risk of cardiovascular events

Issued also as CD

There are no comments on this title.

to post a comment.