Effect of intravenous infusion of lidocaine in comparison to intravenous infusion of dexmedetomidine on proinflammatory cytokines and stress response in pelviabdominal cancer surgeries / Norma Osama AbdAlla Zayed ; Supervised Emad Gerges Saleh , Ekramy Mansour Abdelghfar , Mohammed Mahmoud Hassan

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Norma Osama AbdAlla Zayed

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Material type: Text

TextLanguage: English Publication details: Cairo : Norma Osama AbdAlla Zayed , 2020Description: 107 P . : charts ; 25cmOther title:

تأثير التنقيط الوريدى لعقار الليدوكين مقابل التنقيط الوريدى لعقارالديكسميديتوميدين على السيتوكينات المنشطة للإلتهاب والإستجابة للإجهاد فى العمليات الجراحية لسرطان البطن و الحوض [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Anesthesia and Pain Relief Summary: The cytokine cascade caused by surgical stimulation is complex with various effects on the injured host. Increased production of proinflammatory cytokines from the site of injury causes many systemic changes such as metabolic derangements and hemodynamic instability. Some released cytokines like tumor necrosis factor alpha (TNF-Ü) and Interleukin 6(IL-6) can cause long lasting hyperalgesia. These proinflammatory cytokines change pain signal transmission through cytokine induced release of some neuroactive substances like nitric oxide, oxygen free radicals and excitatory amino acids. On the other hand anti-inflammatory cytokines are also released during inflammation to counteract these effects and keep balance.Dexmedetomidine is a highly selective alpha-2 adrenergic receptor agonist that has sedative, analgesic, anesthetic-sparing properties with no respiratory depression. Its anti-inflammatory effects are being studied. Intravenous lidocaine can be used in management of chronic pain. Intravenous lidocaine also decreases consumption of inhalational anesthetics. It{u201F}s been associated with early recovery of bowel function. Lidocaine has significant anti-inflammatory properties

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Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.19.01.Ph.D.2020.No.E (Browse shelf(Opens below))		Not for loan		01010110083566000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.19.01.Ph.D.2020.No.E (Browse shelf(Opens below))	83566.CD	Not for loan		01020110083566000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Anesthesia and Pain Relief

The cytokine cascade caused by surgical stimulation is complex with various effects on the injured host. Increased production of proinflammatory cytokines from the site of injury causes many systemic changes such as metabolic derangements and hemodynamic instability. Some released cytokines like tumor necrosis factor alpha (TNF-Ü) and Interleukin 6(IL-6) can cause long lasting hyperalgesia. These proinflammatory cytokines change pain signal transmission through cytokine induced release of some neuroactive substances like nitric oxide, oxygen free radicals and excitatory amino acids. On the other hand anti-inflammatory cytokines are also released during inflammation to counteract these effects and keep balance.Dexmedetomidine is a highly selective alpha-2 adrenergic receptor agonist that has sedative, analgesic, anesthetic-sparing properties with no respiratory depression. Its anti-inflammatory effects are being studied. Intravenous lidocaine can be used in management of chronic pain. Intravenous lidocaine also decreases consumption of inhalational anesthetics. It{u201F}s been associated with early recovery of bowel function. Lidocaine has significant anti-inflammatory properties

Issued also as CD

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