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Assessment of tissue perfusion using perfusion index, oxygen deliveryindex and lactate clearance in children with shock / Sherine Ruby Abdelsadak Sultan ; Supervised Hafez Mahmoud Sadek Bazaraa , Heba Allah Fadel Mahmoud Algebaly , Elshimaa Salah Ahmed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Sherine Ruby Abdelsadak Sultan , 2021Description: 190 P . : charts ; 25cmOther title:
  • تقييم ارواء الانسجة باستخدام مؤشر الارواء و مؤشر توصيل الاكسجين و ازاله اللاكتات لدى الاطفال المصابين بالصدمة [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics Summary: Background: pediatric shock carries a high mortality and during early stages, many of the clinical signs are subtle. Its recognition is difficult and requires high index of suspicion. Each of these clinical signs, when considered alone, have poor sensitivity and specificity for outcome prediction. Restoration of global hemodynamics does not always mean that adequate tissue perfusion is achieved. Objective: to evaluate the utility of perfusion index, oxygen delivery index, oxygen consumption index and lactate clearance in the management and outcome prediction in children with shock. Methods: this cross sectional study was conducted on 50 children diagnosed with shock and underwent clinical assessment (heart rate , blood pressure, capillary refill time, CVP), perfusion index detection using Masimo Rad 67 and cardiovascular assessment by ICON (CI, SVRI, Oxygen delivery index (DO2I), laboratory investigations (Scvo2, Lactate through ABG). Calculation of lactate clearance, Oxygen Consumption Index (VO2I) and global oxygen Extraction Ratio (go2ER) was done. Results: males constituted 68% of studied patients. Perfusion Index (PI) ranged from (0.03-2.2), serum lactate ranged from (0-16 mmol/L), lactate clearance ranged from (-52.4% to 95%), DO2I ranged from (148 -1566 ml /min/m2), VO2I ranged from (135 - 325 ml /min/m2), go2ER ranged from (0.14-0.92), cut offs for predicating morality at 12 hour post admission for PI, lactate, lactate clearance, VO2I was {u2264}0.88 (sensitivity 100%, specificity 100%), >3 (sensitivity 95%, specificity 93%), 20% (sensitivity 100%, specificity 100%), >159 (sensitivity 100%, specificity 100%) respectively
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.Ph.D.2021.Sh.A (Browse shelf(Opens below)) Not for loan 01010110083684000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.Ph.D.2021.Sh.A (Browse shelf(Opens below)) 83684.CD Not for loan 01020110083684000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background: pediatric shock carries a high mortality and during early stages, many of the clinical signs are subtle. Its recognition is difficult and requires high index of suspicion. Each of these clinical signs, when considered alone, have poor sensitivity and specificity for outcome prediction. Restoration of global hemodynamics does not always mean that adequate tissue perfusion is achieved. Objective: to evaluate the utility of perfusion index, oxygen delivery index, oxygen consumption index and lactate clearance in the management and outcome prediction in children with shock. Methods: this cross sectional study was conducted on 50 children diagnosed with shock and underwent clinical assessment (heart rate , blood pressure, capillary refill time, CVP), perfusion index detection using Masimo Rad 67 and cardiovascular assessment by ICON (CI, SVRI, Oxygen delivery index (DO2I), laboratory investigations (Scvo2, Lactate through ABG). Calculation of lactate clearance, Oxygen Consumption Index (VO2I) and global oxygen Extraction Ratio (go2ER) was done. Results: males constituted 68% of studied patients. Perfusion Index (PI) ranged from (0.03-2.2), serum lactate ranged from (0-16 mmol/L), lactate clearance ranged from (-52.4% to 95%), DO2I ranged from (148 -1566 ml /min/m2), VO2I ranged from (135 - 325 ml /min/m2), go2ER ranged from (0.14-0.92), cut offs for predicating morality at 12 hour post admission for PI, lactate, lactate clearance, VO2I was {u2264}0.88 (sensitivity 100%, specificity 100%), >3 (sensitivity 95%, specificity 93%), 20% (sensitivity 100%, specificity 100%), >159 (sensitivity 100%, specificity 100%) respectively

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