header
Image from OpenLibrary

Dysregulation of human beta-defensin-1 (hBD-1) in behcet{u2019}s disease : An association with pathophysiology of the disease / Dalia Fouad Mahmoud Elgibaly ; Supervised Dalia Ahmed Ali Labib , Hala Lotfy Fayed , Aliaa Sayed Eldash

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Dalia Fouad Mahmoud Elgibaly , 2021Description: 119 P. : charts , facsimiles ; 25cmOther title:
  • فى مرض بهجت (hBD-1)البشرى defensin-1 عدم تنظيم بيتا : رابطة مع الفسيولوجيا المرضية للمرض [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Background: Behçet's disease (BD) is a multisystem inflammatory disease of unknown etiology. Beta-defensins are antimicrobial peptides involved in epithelial host defense. The purpose of this work is to explore whether beta-defensins might be involved in BD pathogenesis or not in in Egyptian patients. Methodology: This case control study included 40 BD patients fulfilling the criteria of the International Criteria for Behcet's Disease (ICBD), compared to 40 age and sex matched healthy subjects. The -20G/A DEFB1 genotypes were determined by restriction fragment length polymorphism (RFLP) technique and systemic levels of plasma hBD-1 were measured using ELISA technique. Results: Plasma hBD-1 concentration was found to be significantly higher in patients than controls groups (p-value <0.001). No statistical significant difference was found between both groups regarding genotyping of -20G/A DEFB1 gene polymorphism (rs11362), allele frequency. Conclusion: The study findings suggest that hBD-1 is involved in BD pathophysiology, and may be used as a marker for BD and possibly a target for therapeutic intervention
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2021.Da.D (Browse shelf(Opens below)) Not for loan 01010110083803000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2021.Da.D (Browse shelf(Opens below)) 83803.CD Not for loan 01020110083803000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Background: Behçet's disease (BD) is a multisystem inflammatory disease of unknown etiology. Beta-defensins are antimicrobial peptides involved in epithelial host defense. The purpose of this work is to explore whether beta-defensins might be involved in BD pathogenesis or not in in Egyptian patients. Methodology: This case control study included 40 BD patients fulfilling the criteria of the International Criteria for Behcet's Disease (ICBD), compared to 40 age and sex matched healthy subjects. The -20G/A DEFB1 genotypes were determined by restriction fragment length polymorphism (RFLP) technique and systemic levels of plasma hBD-1 were measured using ELISA technique. Results: Plasma hBD-1 concentration was found to be significantly higher in patients than controls groups (p-value <0.001). No statistical significant difference was found between both groups regarding genotyping of -20G/A DEFB1 gene polymorphism (rs11362), allele frequency. Conclusion: The study findings suggest that hBD-1 is involved in BD pathophysiology, and may be used as a marker for BD and possibly a target for therapeutic intervention

Issued also as CD

There are no comments on this title.

to post a comment.