The effect of the montelukast sodium on pregnant albino rats and their fetuses / Mohammed Adel Abdelnaby Ahmed ; Supervised Abdelwahab Elghareeb , Heba Ali Abdelrahman , Islam Mohamad Elgarawani

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

The prevalence of asthma in pregnant women is 4{u2013}12%, making it the most common chronic condition in pregnancy. Montelukast is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene CysLT1 receptor which treat asthma.The objective of the current study was investigating the safety of the Montelukast on the fetus during pregnancy. Pregnant rats (albino Rats) were administrated during gestation period (5th{u2013} 20th) with therapeutic dose 10 mg/kg according to (Wang et al., 2016). At 20th gestation day, the dams were weighed, sacrificed and the laparotomy process was performed with exposure of the uterine horns.The uteri from each female were removed, weighted and opened using a scissor and then the fetuses were separated.Numbers of implantation sites and viable, dead and resorbed fetuses were calculated and mortality rate, growth parameters, morphological and skeletal malformation as well as histological study were observed.The results revealed a significant decrease in the growth parameters in treated animals.Hematomas were noticed in the fetuses of treated group. Skeletal abnormalities included ribs anomalies, weak ossification of the skull bones roof and bones formed girdles and limbs.Our histopathological study showed that Montelukast cause histopathological changes on both fetal & mother liver and brain as well as placenta of albino rats.Depend on the previous hazard effect of Montelukast on pregnancy it is highly recommended that the ASTHMA pregnant women avoiding administrating Montelukast during the pregnant period

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