Thesis (Ph.D.) - Cairo University - Faculty of Physical Therapy - Department of Cardiopulmonary and Geriatric Disorder

Background: Cancer-related fatigue is a persistent symptom in acute myeloid leukemia survivors with associated decreased functional capacity which further deteriorate their quality of life. The current study aimed to find out the impact of aerobic versus resistive training on functional capacity in acute myeloid leukemia (AML) survivors. Methods: Sixty patients with AML from both sexes (34 males and 26 females) aged from 35-45 years were selected from hematology department in Nasser Institute Hospital where the study was conducted. Patients were randomly assigned into two groups; Group (A) underwent aerobic exercises in the form of cycling with 50-60% of maximum heart rate. Group (B) underwent resistive training conducted in the form of a series of exercises using free weights, and dumbles. Sessions were conducted three times /week for eight weeks.Six minutes{u2019} walk test (6MWT), 10 repetitions maximum test (10 RM), ventilatory function test, fatigue and quality of life (QoL) scales were used to assess functional capacity in both groups. Results: Significant improvement in 6MWD, VO2 max and vital capacity in group (A), significant improvement in fatigue and QoL in both groups and significant improvement in 10 RM test in group (B). It was found that both types of exercises improved functional capacity in AML survivors with significant improvement in group (A) more than group (B). Conclusion: Aerobic training significantly improved functional capacity more than resistive training in AML patients

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