Preparation, characterization and biological evaluation of newly formulated nano- radiopharmaceuticals / Dina Mohammed Elsayed Ali Elsafoury ; Supervised Doaa Ahmed Elsetouhy , Omneya Mohamed Khowesah , Mohamed Abdelmotaleb

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

The cancer treatment is a very complex process. One of the main obstacles to conventional chemotherapy is finding a technology to deliver the anticancer agents to the cancer tissues in a specific and controlled manner in order to eliminate cancer cells while keeping healthy cells intact. Nanocarriers (e.g., gold nanoparticles, AuNPs) can deliver them to tumor site at a lower dose and in a controlled manner to overcome the side effects of conventional chemotherapy and increase their therapeutic efficiency. Nuclear medicine has the ability to evaluate not only the anatomy of the target site but also its physiological function and biochemical changes in disease states through molecular imaging techniques (e.g., SPECT and PET). Radiopharmaceutical consists of two main compartments, in addition to radioisotope there is a biologically active molecule that binds with the radioisotope so that they can be directed correctly to the desired site of action.Thus, the combination of nuclear medicine (radiopharmaceuticals) and nanotechnology (AuNPs) achieves an efficient and safe delivery of drugs and radioisotopes to the target organ with minimal exposure to non-target tissues and this can be achieved through nanoradiopharmaceuticals design. Nanoradiopharmaceuticals are considered as new class of therapeutic and / or diagnostic agents with great potential in biomedical applications.The potentiality of nanoradiopharmaceutical in tumor diagnosis and/or treatment are based on radioisotopes{u00B4} decay mode, emission properties and physical half-life

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