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Effect of radial extracorporeal shock wave therapy on induced uterine leiomyoma in experimental rats / Rehab Saber Abdelhamid Mamoon ; Supervised Salwa Mostafa Elbadry , Amel Mohamed Yousef , Amal Mahmoud Aboelmaaty ,

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rehab Saber Abdelhamid Mamoon , 2021Description: 145 P. : charts , facsimiles ; 25cmOther title:
  • تأثير الموجات التصادمية الشعاعية على أورام الرحم الليفية المستحثة فى الفئران التجريبية [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Physical Therapy - Department of Physical Therapy for Gynecology and Obstetrics Summary: Uterine leiomyoma or fibroids are the most common benign tumors in reproductive women. Although their negative impact on women{u2019}s health, there are few conservative treatment options for women suffering from fibroid symptoms. This study was conducted to investigate different doses related to the effect of radial extracorporeal shock wave therapy on induced uterine leiomyoma in rats. Thirty mature virgin female Wister strain rats, weighting 150-190 grams were used in this study; 3 rats used as a negative control group, and the other 27 rats were subjected for induction of leiomyoma. The induced groups (untreated group and 2 experimental groups A& B), were administrated monosodium glutamate (MSG) for 8 weeks, and from the 3rd week; Estradiol benzoate was injected subcutaneously twice per week for 6 weeks. After induction, the induced rats were divided into: 5 rats untreated group, 18 rats treated conservatively with shock wave therapy (SWT) as; 9 rats in group A were treated by Low intensity SWT and 9 rats in group B were treated by High intensity SWT, while the other 4 rats had died during the induction phase. All rats were assessed for developing uterine fibroids with Doppler ultrasonography. The collected blood samples: estradiol (E2), Estrogen receptor (ER), progesterone (P4), and progesterone receptor (PGR), were assayed. Total cholesterol, protein, albumin, and globulin were measured also. Uterine arteries{u2019} blood flow velocities, indices, and volume were obtained.Tissue samples were stained with smooth muscle actin (SMA), trichrome-three, and (hematoxylin and eosin). Rats developed leiomyoma had the highest (P=0.0001) gross and sonographic uterine horns diameters, uterine weight, uterine coefficient, E2, and ER. Both trichrome-three and SMA staining confirmed the leiomyoma development and the response to shock waves treatment. In conclusion, low-intensity and high- intensity radial shock waves are proved to be curative for the induced leiomyoma in rats
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.21.04.Ph.D.2021.Re.E (Browse shelf(Opens below)) Not for loan 01010110084340000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.21.04.Ph.D.2021.Re.E (Browse shelf(Opens below)) 84340.CD Not for loan 01020110084340000

Thesis (Ph.D.) - Cairo University - Faculty of Physical Therapy - Department of Physical Therapy for Gynecology and Obstetrics

Uterine leiomyoma or fibroids are the most common benign tumors in reproductive women. Although their negative impact on women{u2019}s health, there are few conservative treatment options for women suffering from fibroid symptoms. This study was conducted to investigate different doses related to the effect of radial extracorporeal shock wave therapy on induced uterine leiomyoma in rats. Thirty mature virgin female Wister strain rats, weighting 150-190 grams were used in this study; 3 rats used as a negative control group, and the other 27 rats were subjected for induction of leiomyoma. The induced groups (untreated group and 2 experimental groups A& B), were administrated monosodium glutamate (MSG) for 8 weeks, and from the 3rd week; Estradiol benzoate was injected subcutaneously twice per week for 6 weeks. After induction, the induced rats were divided into: 5 rats untreated group, 18 rats treated conservatively with shock wave therapy (SWT) as; 9 rats in group A were treated by Low intensity SWT and 9 rats in group B were treated by High intensity SWT, while the other 4 rats had died during the induction phase. All rats were assessed for developing uterine fibroids with Doppler ultrasonography. The collected blood samples: estradiol (E2), Estrogen receptor (ER), progesterone (P4), and progesterone receptor (PGR), were assayed. Total cholesterol, protein, albumin, and globulin were measured also. Uterine arteries{u2019} blood flow velocities, indices, and volume were obtained.Tissue samples were stained with smooth muscle actin (SMA), trichrome-three, and (hematoxylin and eosin). Rats developed leiomyoma had the highest (P=0.0001) gross and sonographic uterine horns diameters, uterine weight, uterine coefficient, E2, and ER. Both trichrome-three and SMA staining confirmed the leiomyoma development and the response to shock waves treatment. In conclusion, low-intensity and high- intensity radial shock waves are proved to be curative for the induced leiomyoma in rats

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