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The effect of seasonal variations on the incidence of renal flares in Egyptian patients with lupus nephritis : An observational study / Nehal Kamal Saad Abdelgaleel Rakha ; Supervised Tarek Fayad , Jilan Abdelmoniem , Hany Hammad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Nehal Kamal Saad Abdelgaleel Rakha , 2021Description: 76 P. : charts ; 25cmOther title:
  • دراسة تأثيرالتغيرات الموسمية على معدل انتكاس الالتهاب الكلوى الناتج عن مرض الذئبة الحمراء فى قطاع مرضى مصريين [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine Summary: In thisretrospective cohort study, we included200 LN patients attendingthe outpatient clinics at Kasr Al-AiniHospitals. Data about flare periods for each patient was collected by month. Patientswere assessed for specific organinvolvement targeted by SLE disease other than kidneys, therapeutics for SLE,LN duration and treatment phase and revised investigationsof ESR, anti-dsDNA antibodies, serum urea and creatinine, urine analysis and 24-h urinary proteins at the time of LN flare. Renal biopsies were revised for histopathologic classification.Results In renal biopsies, 44% of patients with renal flares had class IV LN,42% had class III, 9.5% had class V, while 4.5% had class II LN.90% of patients were on treatment regimen including HCQ, prednisone and AZA. While 10% had MMF replacing AZA. The highest incidence of flares occurred in June (14%) and July (12.5) (p=0.003)ز Conclusion We determined that there is seasonal variation in the flare of LN. Patients with LN may be expected to have renal flares near summer months. Larger longitudinal studies are needed to determine the efficacy of earlier screeningto detect or prevent flares
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.Ph.D.2021.Ne.E (Browse shelf(Opens below)) Not for loan 01010110084545000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.Ph.D.2021.Ne.E (Browse shelf(Opens below)) 84545.CD Not for loan 01020110084545000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

In thisretrospective cohort study, we included200 LN patients attendingthe outpatient clinics at Kasr Al-AiniHospitals. Data about flare periods for each patient was collected by month. Patientswere assessed for specific organinvolvement targeted by SLE disease other than kidneys, therapeutics for SLE,LN duration and treatment phase and revised investigationsof ESR, anti-dsDNA antibodies, serum urea and creatinine, urine analysis and 24-h urinary proteins at the time of LN flare. Renal biopsies were revised for histopathologic classification.Results In renal biopsies, 44% of patients with renal flares had class IV LN,42% had class III, 9.5% had class V, while 4.5% had class II LN.90% of patients were on treatment regimen including HCQ, prednisone and AZA. While 10% had MMF replacing AZA. The highest incidence of flares occurred in June (14%) and July (12.5) (p=0.003)ز Conclusion We determined that there is seasonal variation in the flare of LN. Patients with LN may be expected to have renal flares near summer months. Larger longitudinal studies are needed to determine the efficacy of earlier screeningto detect or prevent flares

Issued also as CD

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