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The study of brain derived neurotropic factor level and val66met polymorphism of brain derived neurotropic factor gene in patients with type two diabetes mellitus and depression / Mai Mohamed Fawzy Mansour ; Supervised Inass Shaltout , Laila Rashed , Hany Hammad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mai Mohamed Fawzy Mansour , 2021Description: 105 P. : charts , facsimiles ; 25cmOther title:
  • دراسة مستوى العامل العصبى الدماغى و الاشكال المختلفة للجين الخاص بالعامل العصبى الدماغى فى مرضى السكر النوع التانى المصابين بالاكتئاب [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine- Department of Internal Medicine Summary: Background: Due to ageing, obesity and sedentary lifestyles, type 2 diabetes mellitus (T2DM) is currently affecting around 400 million individuals worldwide and is expected to rise rapidly to be affecting 592 million by 2035. Globally, depression and diabetes represent the 4th and 8th cause of disability adjusted life years, respectively. Depression and distress in T2DM are associated with greater morbidity, mortality and healthcare costs. Like many other chronic conditions, T2DM is associated with depression (Nanayakkara et al., 2018). Individuals with diabetes have a 2{u2013}4 fold greater risk of depression when compared to individuals without diabetes (Badescu et al., 2016). Aim:The current case-control study aimed to evaluate the relation between the levels of BDNF and val66met polymorphism of BDNF gene, and the presence of depression in type 2 diabetes. In addition to finding a relation between BDNF level and val66met polymorphism of its gene and assessing relation between BDNF level and obesity.Subjects and Methods:The current study included 88 type 2 diabetic patients, which are further divided into two groups; depressed and non-depressed. Depression was assessed by Hamilton Depression Rating Scale (HAM-D) and structured clinical interview for DSM-IV Axis disorder (SCID-I) for diagnosing depression and exclusion of other psychiatric disorders Genotyping was performed by using Real time-PCR-TaqMan probes
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.Ph.D.2021.Ma.S (Browse shelf(Opens below)) Not for loan 01010110084720000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.Ph.D.2021.Ma.S (Browse shelf(Opens below)) 84720.CD Not for loan 01020110084720000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine- Department of Internal Medicine

Background: Due to ageing, obesity and sedentary lifestyles, type 2 diabetes mellitus (T2DM) is currently affecting around 400 million individuals worldwide and is expected to rise rapidly to be affecting 592 million by 2035. Globally, depression and diabetes represent the 4th and 8th cause of disability adjusted life years, respectively. Depression and distress in T2DM are associated with greater morbidity, mortality and healthcare costs. Like many other chronic conditions, T2DM is associated with depression (Nanayakkara et al., 2018). Individuals with diabetes have a 2{u2013}4 fold greater risk of depression when compared to individuals without diabetes (Badescu et al., 2016). Aim:The current case-control study aimed to evaluate the relation between the levels of BDNF and val66met polymorphism of BDNF gene, and the presence of depression in type 2 diabetes. In addition to finding a relation between BDNF level and val66met polymorphism of its gene and assessing relation between BDNF level and obesity.Subjects and Methods:The current study included 88 type 2 diabetic patients, which are further divided into two groups; depressed and non-depressed. Depression was assessed by Hamilton Depression Rating Scale (HAM-D) and structured clinical interview for DSM-IV Axis disorder (SCID-I) for diagnosing depression and exclusion of other psychiatric disorders Genotyping was performed by using Real time-PCR-TaqMan probes

Issued also as CD

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