Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology

Dexamethasone, a corticosteroid, is analogous to a natural hormone produced by adrenal glands. It is employed to exchange this chemical when your body doesn't make enough of it. It relieves inflammation (swelling, heat, redness, and pain) and is employed to treat certain sorts of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e.g., colitis); severe allergies; and asthma.Dexamethasone is treating certain sorts of cancer. There is studies tells us that administration of dexamethasone to pregnant women increases the risk of birth defect in the offspring and possible also other adverse effect in the exposed infant.The present work studied the ameliorative effect of fennel oil against teratogenic effect induced by the dexamethasone in albino rats.The animals were divided into 4 groups: group 1 (control), group 2: the pregnant rat orally given fennel oil (1 ml/kg body weight), group 3: the pregnant rat orally-administered with human equivalent dose 0.13 mg/Kg dexamethasone and group 4: the pregnant rat orally-administered with dexamethasone followed by fennel oil from 5th day of gestation to 19th day of gestation.The pregnant rats were sacrificed under anesthesia at 20th day of gestation.The uteri horns were isolated, and the numbers of resorbed sites were determined. In addition, the morphological examination and skeletal staining of fetuses and the histological studies on placenta, fetal liver, kidney and brain have been done. The Result showed decrease in both corrected body weight and placenta weight of pregnant mother and high incidence of resorption

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