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Investigation of ameliorative effects of fenugreek seeds and germinated fenugreek seeds on kidney failure induced by gentamicin in swiss albino mice / Marwa Magdy Ebrahim Ali ; Supervised Mahmoud Ahmed Amer , Shebl Abdelmonem Shaalan , Sherin Ramadan Hamad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Marwa Magdy Ebrahim Ali , 2021Description: 72 P. : charts , facsimiles ; 25cmOther title:
  • دراسة تأثير بذور الحلبه والحلبه المستنبته على الفشل الكلوى المستحث بالجنتاميسين ف ى الفئران البيضاء السويسرية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology Summary: Purpose: Gentamicin is an aminoglycoside antibiotic widely used against Gram-negative microorganisms. Nephrotoxicity is the main limitation to its therapeutic efficacy.The aim of work was to investigate the role of dried and germinated fenugreek seeds as a potent antioxidant against the nephrotoxicity and oxidative stress in the kidney tissues. Materials and Methods: 36 Male Swiss albino mice were divided into 6 groups (6 mice in each group) Group I: the animals were injected intraperitoneally with distilled water. Group 2: the animals were intraperitoneally injected with gentamicin. Group 3: the animals were orally received fenugreek (Trigonella foenum -graecum). Group 4: the animals were orally received germinated fenugreek. group5: the animals were intraperitoneally injected with gentamicin simultaneously with fenugreek (Trigonella foenum -graecum). Group 6: the animals were intraperitoneally injected with gentamicin simultaneously with germinated fenugreek. All the treatments of gentamicin were given as (100mg/kg) and all treatments of dried and germinated fenugreek were given as (500mg/kg) a single daily dose for five days. Physiological studies were applied on kidney by measuring kidney function parameters, oxidative stress parameters, as well as histopathological examination. Results: Administration of gentamicin caused blood urea, serum creatinine, uric acid; and Lipid peroxidase, (MDA) levels were raised significantly, while the reduction in levels of reduced glutathione, (GSH); glutathione reductase, (GR); superoxide dismutase, (SOD); and catalase, (CAT) as compared to control. Renal damage was confirmed by histopathological studies. Co-administration of dried and germinated fenugreek along with gentamicin led to significant restoration of blood urea, uric acid, serum creatinine MDA, GSH, GR, SOD, and CAT levels
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2021.Ma.I (Browse shelf(Opens below)) Not for loan 01010110084754000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2021.Ma.I (Browse shelf(Opens below)) 84754.CD Not for loan 01020110084754000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

Purpose: Gentamicin is an aminoglycoside antibiotic widely used against Gram-negative microorganisms. Nephrotoxicity is the main limitation to its therapeutic efficacy.The aim of work was to investigate the role of dried and germinated fenugreek seeds as a potent antioxidant against the nephrotoxicity and oxidative stress in the kidney tissues. Materials and Methods: 36 Male Swiss albino mice were divided into 6 groups (6 mice in each group) Group I: the animals were injected intraperitoneally with distilled water. Group 2: the animals were intraperitoneally injected with gentamicin. Group 3: the animals were orally received fenugreek (Trigonella foenum -graecum). Group 4: the animals were orally received germinated fenugreek. group5: the animals were intraperitoneally injected with gentamicin simultaneously with fenugreek (Trigonella foenum -graecum). Group 6: the animals were intraperitoneally injected with gentamicin simultaneously with germinated fenugreek. All the treatments of gentamicin were given as (100mg/kg) and all treatments of dried and germinated fenugreek were given as (500mg/kg) a single daily dose for five days. Physiological studies were applied on kidney by measuring kidney function parameters, oxidative stress parameters, as well as histopathological examination. Results: Administration of gentamicin caused blood urea, serum creatinine, uric acid; and Lipid peroxidase, (MDA) levels were raised significantly, while the reduction in levels of reduced glutathione, (GSH); glutathione reductase, (GR); superoxide dismutase, (SOD); and catalase, (CAT) as compared to control. Renal damage was confirmed by histopathological studies. Co-administration of dried and germinated fenugreek along with gentamicin led to significant restoration of blood urea, uric acid, serum creatinine MDA, GSH, GR, SOD, and CAT levels

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