Potential therapeutic effect of platelet-rich plasma and albendazole on the muscular phase of experimental trichinella spiralis infection / Fatma Mamdouh Azouz Eissa ; Supervised Ahmed Hemmat Eassa , Rabab Sayed Zalat , Marwa Adel Elmallawany

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Parasitology

Trichinosis is considered one of the most common food-born parasitic infections causing muscle damage and necrosis. This study was done to detect the potential therapeutic effect of platelet rich plasma (PRP) alone and in combination with albendazole (ALB) on the muscular phase of experimental trichinosis in rats. The study was conducted on 70 rats that were divided into the following groups: healthy rats, non-infected rats treated with PRP (seven rats each) and an infected group comprising 56 rats. The infected group was further subdivided according to the received drug therapy. Drug therapy effects were assessed by parasitological and histopathological assessments. Parasitological assessment of the mean numbers of T. spiralis larvae per gm muscle showed the following overall reduction percentages in PRP treated groups (one, two and three doses): 43.1 %, 78.83 % & 86.08 %, respectively. Groups treated with a combined therapy of ALB & PRP (one, two and three doses) showed overall percentages of reduction of 87.68%, 90.88 % & 95.2% respectively. Whereas, the albendazole treated group showed a 69.36% percentage of reduction. All results of the above mentioned treated groups were statistically significant compared to the control infected group Histopathological assessment findings were in correlation with parasitological results, the groups receiving combined therapy showed the most marked improvement in degree of inflammation and fibrosis. It can be concluded that PRP has anti-Trichinella, anti-inflammatory & anti-fibrotic effects on the muscular phase of trichinosis

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