Evaluation of the effect of prolotherapy using two different platelet-rich plasma concentrations on the frequency of luxation and pain of temporomandibular joint subluxationn : A prospective double blind randomized controlled trial / Fawaz Fadhel Abbas Ahmed ; Supervised Hamida Refai Hassanien , Osama Taema

Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine- Department of Oral and Maxillofacial Surgery

The essence of PRP is the platelet concentration above baseline values (whole blood) with the subsequent high content of growth factors that are involved in tissue healing. In vitro studies showed that different concentrations of platelets exhibit different levels of efficacy in inducing proliferation in a non dose-dependent manner. On the other hand, the clinical studies use PRP with different or non specified platelet concentrations and have not yet identified its effect on the efficacy of PRP prolotherapy. Thus it was the aim of this study to evaluate if different concentrations of platelets in PRP have different effects on the clinical outcomes of PRP prolotherapy in patients with symptomatic TMJ hypermobility Thirty four patients with TMJ hypermobility were included in this study (5 male and 29 females) with an average of 29.97 ± 7.34 years old. Using a computer-generated randomization schedule, they were randomly allocated to one of two study arms: the 2intervention3 group who received prolotherapy using low concentration of PRP (L-PRP) or the 2control3 group who received prolotherapy using high concentration of PRP (H-PRP). The allocation concealed from the patients and the study researcher. Each patient received two sessions of intra-articular and pericapsular injections with 2 weeks apart, using either L-PRP or H-PRP. 15 patients received L-PRP (contained 3.43 ± 0.7 times as many platelets as whole blood) and 19 patients received H-PRP (contained 7.10 ± 2.21 times as many platelets as whole blood

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