Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Radio-Diagnosis

Background: Lung cancer is one of the most common malignant tumors in the world.The persistence of nodular ground glass opacity (GGO) over time may be strongly suggestive of an early-stage malignancy. Although ground glass nodules (GGNs) have a high probability of malignancy, a few lesions were benign. Among them, most are transient as inflammation, and hemorrhage.Therefore, carefully discriminating benign GGNs from malignant ones remains a challenge.Radiomics is a recently created term has been introduced in 2012 by Lambin et al. which refers to the process of imaging feature on MSCT extraction and quantitative analysis of tumor entropy by analyzing the distribution and relationship of pixel or voxel gray levels in the image.There are quantifiable texture differ»ences between benign and malignant lesions, possibly allowing pathologic differentiation in certain clinical settings.Methods and results:This study involved 72 patients, age ranged from 27 to 94 years were referred from the outpatient clinic of oncology and chest department of Kasr -Al Ainy Hospital, to perform CT of the chest in the radiology department. There was statistically significant relation between the final diagnosis of lung nodule with size and irregularity index (p- value 0.007). Mean size in cases of malignant nodules was 6.66 mm maximum and 4.26 minimum, but mean size of benign nodules was 11.25 mm maximum and 4.98 minimum (P-Value 0.002)

Issued also as CD