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Epicardial fat, impact on cardiovascular risk factors and relation to atherosclerosis / Ahmed Naguib Sayed Mostafa ; Supervised Mohammed Mahmoud Abdelghany , Abdullah Amin Alagha , Reda Hussein Diab

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Naguib Sayed Mostafa , 2021Description: 202 P. : charts , facsimiles ; 25cmOther title:
  • الدهون فوق القلبية وتأثرها بعوامل الخطورة القلبية الوعائية : وعلاقتها بتصلب الشرايين [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Cardiology Summary: Objectives:To evaluate the association between epicardial fat volume and other cardiovascular risk factors and to evaluate the relation between epicardial fat volume and atherosclerotic coronary artery disease. background: Epicardial adipose tissue is not a simple lipid storage unit; it serves as an endocrine and paracrine organ, having a role in maintaining the homeostasis of body energy and metabolism, and a major source of anti-inflammatory and pro-inflammatory adipokines, which have significant impact on cardiac function and morphology. Epicardial adipose tissue can locally affect the coronary arteries and play a significant role in the development and progression of coronary artery disease (CAD). EAT quantification may be relatively easily done by different imaging techniques. TTE is the most accessible. Cardiac magnetic resonance (CMR) is currently considered the gold standard for EAT quantification. Both thickness and volume can be easily measured by CMR methods:Thisprospectiveobservationalstudywasappliedonpatientswhohadbeenreferred for CMR in a private lab, performed from July 2019 till April 2021.The study included 60 patients. According to the results of previous angiograms and coronary MRA, Patients were categorized into two main groups: Group I (Absent coronary artery disease group), Group II (Present coronary artery disease group). The two groups were assessed for: The clinical presentations and the risk factors (age, sex, smoking, dyslipidemia, hypertension, diabetes, and obesity). Relations between epicardial fat volume (EFV) and cardiovascular risk factors. Relations between EFV and presence or absence of CAD, between EFV and the segmental distribution of the obstructive lesions in the coronary tree in group II, between EFV and the number of the affected vessels in group II. ROC curve analysis performed to detect best cutoff value of epicardial fat volume for detection of obstructive CAD
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.04.Ph.D.2021.Ah.E (Browse shelf(Opens below)) Not for loan 01010110084952000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.04.Ph.D.2021.Ah.E (Browse shelf(Opens below)) 84952.CD Not for loan 01020110084952000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Cardiology

Objectives:To evaluate the association between epicardial fat volume and other cardiovascular risk factors and to evaluate the relation between epicardial fat volume and atherosclerotic coronary artery disease. background: Epicardial adipose tissue is not a simple lipid storage unit; it serves as an endocrine and paracrine organ, having a role in maintaining the homeostasis of body energy and metabolism, and a major source of anti-inflammatory and pro-inflammatory adipokines, which have significant impact on cardiac function and morphology. Epicardial adipose tissue can locally affect the coronary arteries and play a significant role in the development and progression of coronary artery disease (CAD). EAT quantification may be relatively easily done by different imaging techniques. TTE is the most accessible. Cardiac magnetic resonance (CMR) is currently considered the gold standard for EAT quantification. Both thickness and volume can be easily measured by CMR methods:Thisprospectiveobservationalstudywasappliedonpatientswhohadbeenreferred for CMR in a private lab, performed from July 2019 till April 2021.The study included 60 patients. According to the results of previous angiograms and coronary MRA, Patients were categorized into two main groups: Group I (Absent coronary artery disease group), Group II (Present coronary artery disease group). The two groups were assessed for: The clinical presentations and the risk factors (age, sex, smoking, dyslipidemia, hypertension, diabetes, and obesity). Relations between epicardial fat volume (EFV) and cardiovascular risk factors. Relations between EFV and presence or absence of CAD, between EFV and the segmental distribution of the obstructive lesions in the coronary tree in group II, between EFV and the number of the affected vessels in group II. ROC curve analysis performed to detect best cutoff value of epicardial fat volume for detection of obstructive CAD

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