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Effect of Wnt/Ý-catenin pathway alteration in hepatocellular carcinoma cell lines and the possible modulation by bevacizumab / Reem Mahmoud Mohammad Mebed ; Supervised Salwa Farouk Sabet , Nahla Shehata Kotb

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Reem Mahmoud Mohammad Mebed , 2021Description: 89 P. : charts , facsimiles ; 25cmOther title:
  • تاثير تغيير مسار الونت بيتا كاتينين على خطوط خلايا سرطان الكبد البشرى والتحوير المحتمل بواسطة البيفاسيزوماب [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology Summary: As about 90% of colorectal cancers and 50% of hepatocellular carcinoma have activated Wnt/Ý-catenin signaling, the current study aim to examine the effect of knocking down Ý-catenin on the expression of VEGF-A and Slug as well as the apoptosis related genes; NF-mB, FasR and c-Flip in HepG2 cells and the possible alteration of their expression when combined with Bevacizumab. Expression of VEGF-A and Slug was also studied in Caco-2 cells. It is reported in this study that VEGF-A increases significantly in response to Bevacizumab alone in HepG2, while VEGF-A and Slug decreased significantly when Bevacizumab was combined with knocked down Ý-catenin in HepG2. However, Bevacizumab alone is more effective in reducing the expression of those genes in Caco-2. On the other hand, Bevacizumab combined with knocked down Ý-catenin remarkably reduced the level of NF-mB, FasR and c-Flip compared to Bevacizumab only treated HepG2 cells although the difference was not statistically significant
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.Ph.D.2021.Re.E (Browse shelf(Opens below)) Not for loan 01010110085096000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.Ph.D.2021.Re.E (Browse shelf(Opens below)) 85096.CD Not for loan 01020110085096000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology

As about 90% of colorectal cancers and 50% of hepatocellular carcinoma have activated Wnt/Ý-catenin signaling, the current study aim to examine the effect of knocking down Ý-catenin on the expression of VEGF-A and Slug as well as the apoptosis related genes; NF-mB, FasR and c-Flip in HepG2 cells and the possible alteration of their expression when combined with Bevacizumab. Expression of VEGF-A and Slug was also studied in Caco-2 cells. It is reported in this study that VEGF-A increases significantly in response to Bevacizumab alone in HepG2, while VEGF-A and Slug decreased significantly when Bevacizumab was combined with knocked down Ý-catenin in HepG2. However, Bevacizumab alone is more effective in reducing the expression of those genes in Caco-2. On the other hand, Bevacizumab combined with knocked down Ý-catenin remarkably reduced the level of NF-mB, FasR and c-Flip compared to Bevacizumab only treated HepG2 cells although the difference was not statistically significant

Issued also as CD

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