header
Image from OpenLibrary

A pharmaceutical study on dapoxetine / Ibrahim Ahmed Elsaid ; Supervised Omaima N. Elgazayerly , Ahmed A. Aboelwafa

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ibrahim Ahmed Elsaid , 2021Description: 178 P. : charts , facsimiles ; 25cmOther title:
  • دراسة صيدلية على عقار الدبوكستين [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Dapoxetine is a selective serotonin reuptake inhibitor. It is used for the treatment of the depression and premature ejaculation. It should be taken 2{u2013} 3 hours before sexual activity. Its maximum plasma concentration (Cm) is reached 2 hours after oral administration. Dapoxetine is metabolized extensively in the liver and kidney by multiple enzymes such as CyP2D6, CyP3A4, and flavin monooxygenase 1 (FMO1).The major product at the end of the metabolic pathway is circulating dapoxetine Noxide, which is a weak SSRI and contributes no clinical effect. Also, one of the most frequently encountered problems in the oral dapoxetine formulations is the bitter taste. Accordingly, the aim of the research is to prepare various taste-masked fast disintegrating orodispersible formulations in order to offer a faster dissolution rate, rapid onset of action, lower liver metabolism and better patient compliance
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2021.Ib.P (Browse shelf(Opens below)) Not for loan 01010110085222000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2021.Ib.P (Browse shelf(Opens below)) 85222.CD Not for loan 01020110085222000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Dapoxetine is a selective serotonin reuptake inhibitor. It is used for the treatment of the depression and premature ejaculation. It should be taken 2{u2013} 3 hours before sexual activity. Its maximum plasma concentration (Cm) is reached 2 hours after oral administration. Dapoxetine is metabolized extensively in the liver and kidney by multiple enzymes such as CyP2D6, CyP3A4, and flavin monooxygenase 1 (FMO1).The major product at the end of the metabolic pathway is circulating dapoxetine Noxide, which is a weak SSRI and contributes no clinical effect. Also, one of the most frequently encountered problems in the oral dapoxetine formulations is the bitter taste. Accordingly, the aim of the research is to prepare various taste-masked fast disintegrating orodispersible formulations in order to offer a faster dissolution rate, rapid onset of action, lower liver metabolism and better patient compliance

Issued also as CD

There are no comments on this title.

to post a comment.