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Effect of betanin on some biochemical alterations induced by chronic use of analgesics and non-steroidal anti-inflammatory drugs in rats / Noha Nabil Nasr Mohamed ; Supervised Tarek Mohamed Kamal Motawi , Noha Ahmed Elboghdady , Samia Abdelaziz Ahmed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Noha Nabil Nasr Mohamed , 2021Description: 115 P. : charts , facsimiles ; 25cmOther title:
  • تأثير مادة البيتانين على بعض التغيرات الحيوية المستحثة بالإستخدام المزمن للأدوية المسكنة والمضادة للإلتهاب غيرالإسترودية بالجرذان [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry Summary: Background: Paracetamol (PAR) and diclofenac (DF) are two of the most popular consumed analgesics and anti-inflammatory medications. Objective: This study aimed to explore the protective effect of betanin (Bet) against PAR or DF induced multiple cellular damage in rats.Materials and methods: Rats were randomly divided into five groups: Normal control (NC) group rats were given saline only. PAR group rats received PAR (400 mg/kg). PAR/ Bet treated group rats administered PAR plus Bet (25mg/kg). DF group rats received DF (10mg/kg). DF/ Bet treated group rats administered the same previous doses of DF plus Bet. All drugs were given orally by gastric gavage for 28 consecutive days.Results: PAR and DF caused a marked reduction in brain neurotransmitters, thyroid axis hormones, and testosterone serum levels, as well as induced liver and kidney injury, disrupted serum lipid profile, enhanced serum levels of inflammatory and oxidative stress markers, triggered DNA fragmentation and caused drastic changes in the histopathological pictures of brain, liver, and kidney tissues. Bet supplementation succeeded to ameliorate most of the biochemical changes and protected DNA from damage as obtained from comet assay and improved the histopathological features. Conclusion: The foregoing findings accentuated the potential antioxidant and anti-inflammatory effect of Bet against PAR or DF overconsumption
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.Ph.D.2021.No.E (Browse shelf(Opens below)) Not for loan 01010110085240000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.Ph.D.2021.No.E (Browse shelf(Opens below)) 85240.CD Not for loan 01020110085240000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry

Background: Paracetamol (PAR) and diclofenac (DF) are two of the most popular consumed analgesics and anti-inflammatory medications. Objective: This study aimed to explore the protective effect of betanin (Bet) against PAR or DF induced multiple cellular damage in rats.Materials and methods: Rats were randomly divided into five groups: Normal control (NC) group rats were given saline only. PAR group rats received PAR (400 mg/kg). PAR/ Bet treated group rats administered PAR plus Bet (25mg/kg). DF group rats received DF (10mg/kg). DF/ Bet treated group rats administered the same previous doses of DF plus Bet. All drugs were given orally by gastric gavage for 28 consecutive days.Results: PAR and DF caused a marked reduction in brain neurotransmitters, thyroid axis hormones, and testosterone serum levels, as well as induced liver and kidney injury, disrupted serum lipid profile, enhanced serum levels of inflammatory and oxidative stress markers, triggered DNA fragmentation and caused drastic changes in the histopathological pictures of brain, liver, and kidney tissues. Bet supplementation succeeded to ameliorate most of the biochemical changes and protected DNA from damage as obtained from comet assay and improved the histopathological features. Conclusion: The foregoing findings accentuated the potential antioxidant and anti-inflammatory effect of Bet against PAR or DF overconsumption

Issued also as CD

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