Pharmaceutical study on polymeric nanofibers for dermal drug delivery systems / Fatma Elzahraa Assem Ahmed Mohamed Abdelnaby ; Supervised Mohamed Ahmed Elnabarawi , Maha Fadel Mohamed Ali , Mahmoud Hassan Teaima

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

As a general rule, time-consuming wound healing process is vulnerable to any exogenous biological attack like bacteria (e.g. Bacillus subtilis, Escherichia coli, Staphylococcus aureus, etc.) that promote wound infection and have an adverse impact on the immune system. Cconsequently, it is vital to generate a convenient method for wound healing with the help of a suitable barrier. In fact, diverse wound protection topical formulations, such as hydrogels, films, emulsions, and nanofibers, have been investigated throughout the last few decades. A drug-embedded nanofiber is composed of a matrix with high biocompatibility and biodegradability, such as chitin, chitosan, and hyaluronic acid as natural polymers, and synthetic polymers such as polyvinyl alcohol, polyethylene oxide, and poly lactic acid loaded with antibiotics or nanoparticles.This is in addition to a drug with excellent antibacterial and antimicrobial properties, as well as certain drugs that stimulate vasodilation and improves in-vascular permeability.They result in a rush of immune cells into the injured tissue, hence decreasing healing time.Actually, biocompatible crosslinked electrospun Polyvinyl alcohol/Chitosan reduced gold nanoparticles and Ý- cyclodextrin (PVA/Cs(Rg)/Ý-CD) in pure water were fabricated.To this end, supportive PVA as a carrier, Cs bio modifier, gold reductant, and Ý-CD as smoother, inclusion guest molecule and capping agent exhibit efficient entrapment of moxifloxacin (Mox) and consequently accelerate release

Issued also as CD