Clinical and radiographic evaluation of injectable platelet rich fibrin (I-PRF) with demineralized freeze-dried bone allograft (DFDBA) compared to demineralized freeze-dried bone allograft (DFDBA) in treatment of intraosseous defects in patients with stage III periodontitis : A randomized clinical trial / Mashaal Mohammed Abdullah ; Supervised Manal Mohamed Hosny , Karim Mohamed Fawzy , Weam Ahmed Elbattawy

Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology

Aim: The aim of the present clinical study is to assess the gain in clinical attachment level gain, reduction in probing pocket depth, and radiographic bone fill following open flap debridement and application of i-PRF in combination with DFDBA compared to open flap debridement and DFDBA alone in the surgical treatment of periodontal intrabony defects in patients with stage-III periodontitis. Methodology: Twenty intrabony defects in 20 stage-III periodontitis patients were selected and randomized equally (10 per each group) into intervention group, where open flap debridement was performed with the application of injectable-platelet rich fibrin (i-PRF) combined with demineralized freeze-dried bone allograft (DFDBA), and control group where open flap debridement application of DFDBA alone. All the selected sites were assessed with the clinical and radiographic parameters such as clinical attachment level (CAL; primary outcome), probing pocket depth (PPD), gingival recession depth (GRD), full mouth plaque score (FMPS), full mouth bleeding score (FMBS), post-surgical patient satisfaction questionnaire, radiographic linear defect depth (RDLL), and radiographic bone fill (IBD) (PPD, GRD, FMPS, FMBS, satisfaction questionnaire, IBD and RLDD; secondary outcomes).All the clinical and radiographic parameter values obtained at different follow up intervals (baseline, 3, 6, and 9 months) were subjected to statistical analysis

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