Thesis (Ph.D.) - Cairo University - Faculty of Physical Therapy - Department of Growth and Development Disorders in Pediatrics

Objectives: To assess the existence of subtle myocardial dysfunctions in children with GBS. Also to investigate the effect of progressive resistive in bed cycling exercises on myocardial and motor function status in children with GBS. Finally, to correlate the myocardial status of these children with their motor recovery status. Subjects and Methods: Our research studied 40 GBS children with myocardial dysfunction, 3-15 years old of both sexes, forty healthy children were also recruited to benchmark the echocardiographic parameters. GBS children were then divided into 2 groups (group A contains 20 GBS children reserving conventional physiotherapy and group B includes 20 GBS children reserving conventional physiotherapy in addition to progressive resistive cycle exercises). Patients were assessed pre- and post- intervention with 3D echocardiography for measuring left ventricle (LV) ejection fraction (EF) and left ventricle global longitudinal strain (LV GLS), also tissue doppler imaging to measure diastolic wave ratio LV E/E' and right ventricle diastolic wave ratio RV E/E'. finally motor functional measure (MFM) scale was also used. Results: Statistical significant was detected in all measured variables in both groups post treatment in favor of the study group indicating effectiveness of the intervention. Significant correlations were observed between MFM and all myocardial performance indices LV E/E{u2032} (r={u2212}0.51 p=0.001), RV E/E{u2032} (r=-0.51, p=0.001), LV 3D EF (r=- 0.38, p=0.016) and 3D LVGLS - r 0.37, p=0.02

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