Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Gynecology and Obstetrics

Background; Hypertensive disorders of pregnancy (HDP) are among the leading causes of maternal and fetal morbidity and mortality. New guidelines and findings from clinical trials must be taken into account so that the diagnosis and treatment of HDP can be optimized, Aim and objectives; to assess and compare the changes of fetal Doppler indices (MCA, UA and DV) in singleton pregnancies complicated by Hypertensive disorders of pregnancy and IUGR from 32 to 34 weeks of gestation after proper dosing and interval of corticosteroid therapy and its impact on fetal outcome, Subjects and methods;This study is a comparative study, carried out at Kasr Al_Aini Hospital, Cairo University, on 80 women with singleton pregnancy divided into 2 Groups: (Group A); Included 40 patients that received corticosteroid therapy in third trimester (from 32 to 34 weeks) to stimulate fetal lung maturity, (Group B); Included 40 patients that received corticosteroid therapy in third trimester (from 32 to 34 weeks) but either dose or interval criteria were not met because of the need to terminate pregnancy, from March 2021 till September 2021, Result;there was high statistically significant difference between the doppler results before and after corticosteroid therapy, Conclusion; Corticosteroid administration to hypertensive women is associated with improvement of all Doppler indices. Although corticosteroid administration was associated with all these Doppler indices enhancement but there was no associated improvement in the number of fetuses born suffering from tachypnea or admitted to NICU when compared to the other group of women who did not complete the proper dose and/or interval of corticosteroid therapy

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