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Molecular Classification of Breast Cancer / Mohamed Abdalla Mohamed Aly Zaakouk; Supervised Emad-Eldin Hamza El-Gemeie, Abeer Shaaban, Mervat El-Deftar

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohamed Abdalla Mohamed Aly Zaakouk , 2021Description: 124p. : Charts, facsimiles ; 25cmOther title:
  • التصنيف الجزيئي لسرطان الثدي [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Pathology Summary: Introduction: Breast cancer (BC) is the most common cancer among females & the leading cause of cancer related death. BC in females of ethnic origin remains poorly understood & management strategies for those patients are derived from the Caucasian disease. Aim of the work: Describing the clinico-pathologic characteristics of BC in ethnic patients. Mapping the immune tumor microenvironment (TME) in BC of ethnic patients. Identifying the frequency & pathogenicity of germline variants in BRCA1/2 & other genes. Patients and Methods: Clinico-pathologic characteristics of 750 cases have been studied. 233 have been immune-stained to study TME. 159 were genetically tested to detect germline variants. Results: Median age at diagnosis was 51 years old. Grade 2&3 cancers constituted 87.4%. More than third were hormone receptor negative & positive axillary lymph nodes were found in 45%. CD4 was the dominant phenotype in 70.8%. T-helper cells correlated with better overall survival (OS) (P 0.029). T-regulatory cells & tumor associated macrophages (TAMs) correlated negatively with OS (P 0.046 & 0.014, respectively). B-cells were associated with good prognosticators. Genetic testing identified 34 pathogenic variants in the tested 159 patients (31.45%). These variants were categorized as 30 pathogenic, 16 variants of uncertain significance (VUS) and 4 non-pathogenic. Conclusions: Non-Caucasian BCs present at a younger age & predominantly symptomatic at time of presentation. These were associated with bad prognosticators & shorter OS. These cancers were of high grade & large size. TME immune cells correlated clinical data, tumour pathologic features & OS. Hence, mapping of TME could provide useful prognostic information. Detected BRCA1/2 pathogenic variants are higher than those reported in white Caucasian patients.
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.03.Ph.D.2021.Mo.M (Browse shelf(Opens below)) Not for loan 01010110085610000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.03.Ph.D.2021.Mo.M (Browse shelf(Opens below)) 85610.CD Not for loan 0102011008561000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Pathology

Introduction: Breast cancer (BC) is the most common cancer among females & the leading cause of cancer related death. BC in females of ethnic origin remains poorly understood & management strategies for those patients are derived from the Caucasian disease. Aim of the work: Describing the clinico-pathologic characteristics of BC in ethnic patients. Mapping the immune tumor microenvironment (TME) in BC of ethnic patients. Identifying the frequency & pathogenicity of germline variants in BRCA1/2 & other genes. Patients and Methods: Clinico-pathologic characteristics of 750 cases have been studied. 233 have been immune-stained to study TME. 159 were genetically tested to detect germline variants. Results: Median age at diagnosis was 51 years old. Grade 2&3 cancers constituted 87.4%. More than third were hormone receptor negative & positive axillary lymph nodes were found in 45%. CD4 was the dominant phenotype in 70.8%. T-helper cells correlated with better overall survival (OS) (P 0.029). T-regulatory cells & tumor associated macrophages (TAMs) correlated negatively with OS (P 0.046 & 0.014, respectively). B-cells were associated with good prognosticators. Genetic testing identified 34 pathogenic variants in the tested 159 patients (31.45%). These variants were categorized as 30 pathogenic, 16 variants of uncertain significance (VUS) and 4 non-pathogenic. Conclusions: Non-Caucasian BCs present at a younger age & predominantly symptomatic at time of presentation. These were associated with bad prognosticators & shorter OS. These cancers were of high grade & large size. TME immune cells correlated clinical data, tumour pathologic features & OS. Hence, mapping of TME could provide useful prognostic information. Detected BRCA1/2 pathogenic variants are higher than those reported in white Caucasian patients.

Issued also as CD

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