Post Covid-19 Retinal Evaluation Using Optical Coherence Tomography Angiography / Ramy Emad Nageeb Louz ; Supervised Tamer Ahmed Macky , Mohamad Amr Salaheddin , Doaa Ahmed Abdelrahman Tolba

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Ramy Emad Nageeb Louz

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TextLanguage: English Publication details: Cairo : Ramy Emad Nageeb Louz , 2021Description: 84 P . : charts , facsimiles , photographs ; 25cmOther title:

تقييم حالة الشبكية فى حالات الشفاء من فايروس كورونا المستجد باستخدام التصوير البصرى الوعائى الدموى المقطعى التوافقى [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Ophthalmology Summary: Purpose: To study the effect of COVID-19 on retinal structure and vasculature by Optical Coherence Tomography Angiography (OCTA) Patients and methods: 90 eyes of 45 patients who recovered & terminated their isolation from COVID-19 infections were compared to 90 eyes of 45 age and gender matched control. All the data regarding the COVID -19 infection were analyzed including clinical manifestations, CT chest, CBC and inflammatory markers as CRP, serum ferritin, D dimer test, and different therapies used. After meticulous ocular examination, we performed retinal OCTA to assess foveal thickness and vasculature. Primary outcomes parameters: comparing all OCTA parameters and detection of any retinal structure or vascular changes between cases and healthy group Results: Foveal avascular zone (FAZ) area was significantly larger in post COVID-19 cases (p=0.032). Post COVID-19 cases had significant lower vascular density (VD) values in all perifoveal quadrants of the superficial capillary plexus (SCP). They also had lower VD in the whole area, parafoveal, temporal & inferior perifoveal areas in the deep capillary plexus (DCP). There was a statistically significant negative linear correlation between CRP and temporal foveal SCP, (p=0.010), DCP whole area (p=0.003), para foveal DCP (p=0.038). Conclusion: This study reported decreased retinal VD and FAZ enlargement in COVID-19 patients compared to age- and sex-matched controls. The evaluation of retinal circulation represents a promising tool in the in vivo study of microvascular involvement in COVID-19 patients. Thus, OCTA could represent a valid biomarker of systemic vascular dysfunction post COVID-19

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Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.24.M.Sc.2021.Ra.P (Browse shelf(Opens below))		Not for loan		01010110085674000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.24.M.Sc.2021.Ra.P (Browse shelf(Opens below))	85674.CD	Not for loan		01020110085674000

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Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Ophthalmology

Purpose: To study the effect of COVID-19 on retinal structure and vasculature by Optical Coherence Tomography Angiography (OCTA) Patients and methods: 90 eyes of 45 patients who recovered & terminated their isolation from COVID-19 infections were compared to 90 eyes of 45 age and gender matched control. All the data regarding the COVID -19 infection were analyzed including clinical manifestations, CT chest, CBC and inflammatory markers as CRP, serum ferritin, D dimer test, and different therapies used. After meticulous ocular examination, we performed retinal OCTA to assess foveal thickness and vasculature. Primary outcomes parameters: comparing all OCTA parameters and detection of any retinal structure or vascular changes between cases and healthy group Results: Foveal avascular zone (FAZ) area was significantly larger in post COVID-19 cases (p=0.032). Post COVID-19 cases had significant lower vascular density (VD) values in all perifoveal quadrants of the superficial capillary plexus (SCP). They also had lower VD in the whole area, parafoveal, temporal & inferior perifoveal areas in the deep capillary plexus (DCP). There was a statistically significant negative linear correlation between CRP and temporal foveal SCP, (p=0.010), DCP whole area (p=0.003), para foveal DCP (p=0.038). Conclusion: This study reported decreased retinal VD and FAZ enlargement in COVID-19 patients compared to age- and sex-matched controls. The evaluation of retinal circulation represents a promising tool in the in vivo study of microvascular involvement in COVID-19 patients. Thus, OCTA could represent a valid biomarker of systemic vascular dysfunction post COVID-19

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